3,757 results found
    1. Neuroscience

    Motor cortex can directly drive the globus pallidus neurons in a projection neuron type-dependent manner in the rat

    Fuyuki Karube et al.
    Globus pallidus neurons projecting to the striatum are preferentially activated by direct glutamatergic innervation from the motor cortex.
    1. Cell Biology

    Negative regulation of autophagy by UBA6-BIRC6–mediated ubiquitination of LC3

    Rui Jia, Juan S Bonifacino
    An ensemble of the ubiquitin-activating enzyme UBA6 and ubiquitin-conjugating enzyme/ubiquitin-ligase BIRC6 mediates ubiquitination of LC3, targeting the latter for proteasomal degradation and thus attenuating autophagic degradation of cellular substrates.
    1. Cell Biology
    2. Neuroscience

    A proline-rich motif on VGLUT1 reduces synaptic vesicle super-pool and spontaneous release frequency

    Xiao Min Zhang et al.
    In mammals, the vesicular glutamate transporter 1 acquired a proline-rich sequence that negatively regulates the spontaneous release of glutamate by reducing the exchange of synaptic vesicles along the axon.
    1. Cell Biology

    Function of hTim8a in complex IV assembly in neuronal cells provides insight into pathomechanism underlying Mohr-Tranebjærg syndrome

    Yilin Kang et al.
    A neuronal specific function of the mitochondrial chaperone, hTim8a in Complex IV biology provides insight into the pathomechanisms underlying the mitochondrial disease, Mohr-Tranebjaerg syndrome.
    1. Developmental Biology

    Mask family proteins ANKHD1 and ANKRD17 regulate YAP nuclear import and stability

    Clara Sidor et al.
    The MASK family of proteins regulate the action of the YAP/TAZ family of transcriptional coactivators, key regulators of stem cell proliferation and cancer.
    1. Cell Biology
    2. Developmental Biology

    Multiplex live single-cell transcriptional analysis demarcates cellular functional heterogeneity

    Ayhan Atmanli et al.
    A novel live-cell mRNA imaging technology identifies individual living cells based on their gene expression and enables the concurrent study of their physiology.
    1. Neuroscience

    Brain clusterin protein isoforms and mitochondrial localization

    Sarah K Herring et al.
    Identification and characterization of multiple brain clusterin isoforms, including a mitochondrial matrix-targeted isoform, provides foundation to potentially clarify the link between these proteins and the development of late-onset Alzheimer’s disease.
    1. Developmental Biology

    Multifaceted roles of microRNAs: From motor neuron generation in embryos to degeneration in spinal muscular atrophy

    Tai-Heng Chen, Jun-An Chen
    Summary review of microRNA roles during motor neuron generation and degeneration.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    In vivo Firre and Dxz4 deletion elucidates roles for autosomal gene regulation

    Daniel Andergassen et al.
    The X-linked loci Firre and Dxz4 are involved in autosomal gene regulation rather than XCI biology.
    1. Structural Biology and Molecular Biophysics
    2. Biochemistry and Chemical Biology

    Protein polyglutamylation catalyzed by the bacterial calmodulin-dependent pseudokinase SidJ

    Alan Sulpizio et al.
    The pseudokinase-like Legionella effector SidJ catalyzes the glutamylation of bacterial ubiquitin ligases in a calmodulin-dependent manner.

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