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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters

    Zachary Lee Johnson et al.
    Studies of the substrate selectivity of concentrative nucleoside transporters provide proof of principle for structure-based improvement of drug delivery by these transporters.
    1. Cell Biology
    2. Computational and Systems Biology

    Perturbation biology nominates upstream–downstream drug combinations in RAF inhibitor resistant melanoma cells

    Anil Korkut et al.
    Data-driven systems biology models of signaling predict cellular response to untested perturbations and can nominate drug combinations to overcome drug resistance in cancer cells.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Knockout of Slo2.2 enhances itch, abolishes KNa current, and increases action potential firing frequency in DRG neurons

    Pedro L Martinez-Espinosa et al.
    Sodium-activated potassium ion currents encoded by the kcnt1 gene delay action potential firing in DRG neurons by activity preceding an action potential.
    1. Cell Biology

    Duodenum Intestine-Chip for preclinical drug assessment in a human relevant model

    Magdalena Kasendra et al.
    Combining Organs-on-Chips technology with adult intestinal organoids provides an improved model of human duodenum and a new platform for preclinical drug assessment.
    1. Cancer Biology
    2. Structural Biology and Molecular Biophysics

    Dynamics of human protein kinase Aurora A linked to drug selectivity

    Warintra Pitsawong et al.
    Slow conformational changes after drug binding rationalize selectivity, affinity and long on-target residence time for kinase inhibitors.
    1. Evolutionary Biology

    More effective drugs lead to harder selective sweeps in the evolution of drug resistance in HIV-1

    Alison F Feder et al.
    The transition from bad to good treatments for HIV was accompanied by a shift from soft sweeps of many drug resistance mutations spreading simultaneously to harder sweeps of one drug resistant genotype at a time.
    1. Chromosomes and Gene Expression
    2. Human Biology and Medicine

    Dominant drug targets suppress the emergence of antiviral resistance

    Elizabeth J Tanner et al.
    When antiviral compounds target oligomeric assemblages, the formation of chimeric oligomers within cells can negate selection for naturally occurring drug-resistant variants.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    The evolution of drug resistance in clinical isolates of Candida albicans

    Christopher B Ford et al.
    Loss-of-heterozygosity mutations, but not aneuploidies, are linked to the evolution of drug resistance in Candida albicans isolated from immunocompromised patients.
    1. Human Biology and Medicine

    Cancer: Designer antiandrogens join the race against drug resistance

    Jatinder S Josan, John A Katzenellenbogen
    Insight
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