56 results found
    1. Neuroscience

    Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss

    Adelaida M Celaya et al.
    Mitogen-activated protein kinase phosphatase 1 (DUSP1) deficiency causes early redox imbalance and increased inflammatory response in the cochlea, leading to cell loss and progressive neurosensory hearing loss.
    1. Cancer Biology

    Hyperactivation of ERK by multiple mechanisms is toxic to RTK-RAS mutation-driven lung adenocarcinoma cells

    Arun M Unni et al.
    Cancer cells driven by mutations in KRAS or EGFR are dependent on DUSP6 to prevent ERK-induced cell death, creating a novel vulnerability for targeted therapy.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Translational control of ERK signaling through miRNA/4EHP-directed silencing

    Seyed Mehdi Jafarnejad et al.
    ERK/MAPK activity is regulated by the cap-binding protein 4EHP, via translational control of the DUSP6 phosphatase.
    1. Biochemistry and Chemical Biology

    GPIHBP1 expression in gliomas promotes utilization of lipoprotein-derived nutrients

    Xuchen Hu et al.
    The expression of the lipoprotein lipase (LPL) transporter GPIHBP1 in glioma capillaries promotes the LPL-mediated processing of triglyceride-rich lipoproteins, thereby providing lipid nutrients for glioma cells.
    1. Developmental Biology

    Lin28a/let-7 pathway modulates the Hox code via Polycomb regulation during axial patterning in vertebrates

    Tempei Sato et al.
    Genetic analyses reveal that the loss of Lin28a causes axial shortening with mild skeletal transformations via decreased PRC1 at Hox genes, establishing a new pathway in the “Hox code.”.
    1. Cell Biology
    2. Developmental Biology

    Notch signaling restricts FGF pathway activation in parapineal cells to promote their collective migration

    Lu Wei et al.
    Notch signaling controls the collective migration of parapineal cells through its capacity to restrict FGF pathway activation to a few leading cells.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Two locus inheritance of non-syndromic midline craniosynostosis via rare SMAD6 and common BMP2 alleles

    Andrew T Timberlake et al.
    Epistatic interactions of rare loss of function mutations in SMAD6 and a common variant modifier near BMP2 are the most common cause of midline craniosynostosis in humans.
    1. Cancer Biology
    2. Cell Biology

    One reporter for in-cell activity profiling of majority of protein kinase oncogenes

    Iva Gudernova et al.
    A new luciferase and fluorescent reporter system enables rapid and efficient in-cell profiling of the majority of protein kinase oncogenes known to date.
    1. Cell Biology
    2. Developmental Biology

    Proliferation-independent regulation of organ size by Fgf/Notch signaling

    Agnė Kozlovskaja-Gumbrienė et al.
    Cell adhesion regulates organ size in the zebrafish lateral line system.
    1. Cancer Biology

    BRAFV600E cooperates with CDX2 inactivation to promote serrated colorectal tumorigenesis

    Naoya Sakamoto et al.
    Genetic analyses reveal how CDX2 and BRAF defects seen in serrated colorectal cancer (CRCs), a poor prognosis CRC subset, cooperate in tumorigenesis in humans and in a mouse cancer model.

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