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    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Two locus inheritance of non-syndromic midline craniosynostosis via rare SMAD6 and common BMP2 alleles

    Andrew T Timberlake et al.
    Epistatic interactions of rare loss of function mutations in SMAD6 and a common variant modifier near BMP2 are the most common cause of midline craniosynostosis in humans.
    1. Developmental Biology

    T-box3 is a ciliary protein and regulates stability of the Gli3 transcription factor to control digit number

    Uchenna Emechebe et al.
    The transcription and splicing factor T-box3 is present in primary cilia, regulates multiple aspects of limb development, and interacts with members of the protein complex required for the stability and processing of the Gli3 transcription factor.
    1. Cell Biology
    2. Developmental Biology

    Proliferation-independent regulation of organ size by Fgf/Notch signaling

    Agnė Kozlovskaja-Gumbrienė et al.
    Cell adhesion regulates organ size in the zebrafish lateral line system.
    1. Cancer Biology

    KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer

    Elsa B Krall et al.
    Loss of KEAP1 modulates sensitivity to targeted therapies in lung cancer.
    1. Immunology and Inflammation

    Single-cell transcriptome reveals the novel role of T-bet in suppressing the immature NK gene signature

    Chao Yang et al.
    T-bet suppresses the expression of immature NK cell-defining genes.
    1. Developmental Biology

    Position- and Hippo signaling-dependent plasticity during lineage segregation in the early mouse embryo

    Eszter Posfai et al.
    Lineage specification and commitment are synchronized in the developing trophectoderm lineage of the mouse embryo, but are asynchronous events in the maturing inner cell mass, revealing a window of plasticity in this lineage.
    1. Computational and Systems Biology
    2. Neuroscience

    Blood transcriptome based biomarkers for human circadian phase

    Emma E Laing et al.
    An unbiased modelling approach shows that only a few blood transcriptome samples are required to accurately assess the human circadian melatonin phase, even during altered sleep schedules.
    1. Neuroscience

    Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis

    Shuo-Chien Ling et al.
    Elevating FUS level by saturating autoregulation loop in mice causes aggressive motor neuron disease via disrupting protein and RNA homeostasis.
    1. Computational and Systems Biology
    2. Stem Cells and Regenerative Medicine

    A protein phosphatase network controls the temporal and spatial dynamics of differentiation commitment in human epidermis

    Ajay Mishra et al.
    A combination of transcriptomics, proteomics and modelling identifies a network of interacting protein phosphatases that act as a biological switch to move cells from the stem cell compartment to the differentiated compartment in cultured human epidermis.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Global analysis of gene expression reveals mRNA superinduction is required for the inducible immune response to a bacterial pathogen

    Kevin C Barry et al.
    Infected cells superinduce expression of mRNA in order to initiate an immune response to a bacterial pathogen that blocks host protein synthesis.