47 results found
    1. Neuroscience

    Sloppy morphological tuning in identified neurons of the crustacean stomatogastric ganglion

    Adriane G Otopalik et al.
    Reliable neuronal physiology can arise from variable and inefficient morphologies.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Protein biogenesis machinery is a driver of replicative aging in yeast

    Georges E Janssens et al.
    A comprehensive mapping of the proteome and transcriptome during the complete replicative lifespan of budding yeast predicted an increased abundance of the protein biogenesis machinery is most causal for aging.
    1. Cell Biology
    2. Neuroscience

    Active presynaptic ribosomes in the mammalian brain, and altered transmitter release after protein synthesis inhibition

    Matthew S Scarnati et al.
    Local presynaptic protein synthesis occurring at established nerve terminals in the mammalian brain provides a mechanism for rapidly controlling or restoring presynaptic proteins that affect neurotransmitter release and presynaptic efficiency.
    1. Neuroscience

    The hippocampus supports deliberation during value-based decisions

    Akram Bakkour et al.
    The deliberation involved in simple preference decisions, such as those between two familiar snacks, depends on the hippocampus.
    1. Neuroscience

    An inhibitory gate for state transition in cortex

    Stefano Zucca et al.
    Two major subtypes of cortical interneurons, the PV and the SST positive cells, causally contribute to the regulation of large-scale state transitions in the cortex.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Continuous transport of a small fraction of plasma membrane cholesterol to endoplasmic reticulum regulates total cellular cholesterol

    Rodney Elwood Infante, Arun Radhakrishnan
    A post-lysosomal cholesterol transport inhibitor reveals how the endoplasmic reticulum membrane regulates total cellular cholesterol by constantly monitoring a critical pool of cholesterol in the plasma membrane.
    1. Developmental Biology
    2. Evolutionary Biology

    The evolutionary origin of bilaterian smooth and striated myocytes

    Thibaut Brunet et al.
    Molecular profiling of annelid myocytes reveals that the last common protostome-deuterostome ancestor already possessed a dual musculature, with visceral smooth muscles ensuring digestion and somatic striated muscles ensuring locomotion.
    1. Cell Biology
    2. Human Biology and Medicine

    A novel GSK3-regulated APC:Axin interaction regulates Wnt signaling by driving a catalytic cycle of efficient ╬▓catenin destruction

    Mira I Pronobis et al.
    A new dynamic mechanistic model explains how the destruction complex negatively regulates Wnt signaling in development and oncogenesis.
    1. Neuroscience

    Circuit mechanisms encoding odors and driving aging-associated behavioral declines in Caenorhabditis elegans

    Sarah G Leinwand et al.
    Neurotransmission pathways from primary to secondary neurons encode odor and underlie age-related sensory behavioral declines.
    1. Microbiology and Infectious Disease

    A randomized feasibility trial comparing four antimalarial drug regimens to induce Plasmodium falciparum gametocytemia in the controlled human malaria infection model

    Isaie J Reuling et al.
    Controlled human malaria infection model allows the study of gametocyte biology and dynamics providing novel insights and tools in malaria transmission and elimination efforts.

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