Predictable patterns of fitness evolution observed in microbial evolution experiments can emerge generically as a consequence of widespread epistatic interactions between mutations.

A combination of massively parallel reporter assays and mass spectrometry uncovers the regulation of previously unexplored promoters across the Escherichia coli genome.

Gating currents analysis at different Ca²⁺ concentrations of BK channels reveals a strong allosteric coupling between Ca²⁺- and voltage-sensing modules via equivalent contributions exerted by the RCK1 and RCK2 Ca²⁺-sites.

For many bacterial species, recombination dominates genome evolution and phylogenetic patterns that have so far been assumed to reflect clonal relationships, in fact reflect variation in recombination rates across lineages.

A new machine-learning toolbox unveils coevolutionary protein motifs related to structure, function, and phylogeny from sequence information only.

Binding of progesterone receptor and transcription factor PAX2 to pre-assembled permissive chromatin compartments regulates endometrial cancer gene expression under estrogenic conditions.

An MTF2-containing subcomplex of Polycomb Repressive Complex 2 promotes cell cycle progression through repression of D-type cyclin expression in certain cellular contexts.

BASH MaP quantitatively reveals alternative RNA tertiary structures by enabling dimethyl sulfate to probe the presence of nucleobase interactions on the Watson-Crick and Hoogsteen faces of single RNA molecules.