13 results found
    1. Structural Biology and Molecular Biophysics

    Single-molecule observation of ATP-independent SSB displacement by RecO in Deinococcus radiodurans

    Jihee Hwang et al.
    RecO efficiently displaces SSB from ssDNA without consuming ATPs using its two DNA-binding sites, even though SSB binds to ssDNA approximately 300 times more strongly than RecO does.
    1. Structural Biology and Molecular Biophysics

    The primary structural photoresponse of phytochrome proteins captured by a femtosecond X-ray laser

    Elin Claesson et al.
    Time-resolved crystallography provides insight into the photochemical reactions in photoreceptor proteins, explaining the earliest steps of how plants, fungi and bacteria sense red light.
    1. Structural Biology and Molecular Biophysics

    Phytochrome Photoreceptors: Rapid response

    Jon Hughes
    Extremely short X-ray pulses from a free-electron laser are helping to clarify how phytochromes respond to light, but puzzles remain.
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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mechanistic basis of the inhibition of SLC11/NRAMP-mediated metal ion transport by bis-isothiourea substituted compounds

    Cristina Manatschal et al.
    The structural and mechanistic characterization of competitive inhibition of human DMT1 offers a promising route for the development of compounds for the treatment of iron overload disorders.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structures in multiple conformations reveal distinct transition metal and proton pathways in an Nramp transporter

    Aaron T Bozzi et al.
    Nramp-family transporters adapt a common fold to a novel mechanism in which the spatial and temporal separation of like-charge transition metal and proton co-substrates circumvents the expected electrostatic repulsion.
    1. Biochemistry and Chemical Biology

    Random-sequence genetic oligomer pools display an innate potential for ligation and recombination

    Hannes Mutschler et al.
    Random sequence RNA pools display an innate capacity for ligation and recombination, enabling them to “bootstrap” themselves towards higher compositional, informational and structural complexity.
    1. Microbiology and Infectious Disease

    Kasugamycin potentiates rifampicin and limits emergence of resistance in Mycobacterium tuberculosis by specifically decreasing mycobacterial mistranslation

    Swarnava Chaudhuri et al.
    Kasugamycin potentiates rifampicin killing of Mycobacterium tuberculosis by targeting adaptive mistranslation.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Asymmetric activation mechanism of a homodimeric red light-regulated photoreceptor

    Geoffrey Gourinchas et al.
    Molecular insights to phytochrome activation and signal transduction over long distances enable the allosteric regulation of enzymatic effectors.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Mechanism for nuclease regulation in RecBCD

    Martin Wilkinson et al.
    DNA unwinding triggers a conformational change in the RecD subunit of E. coli RecBCD helicase-nuclease that is transferred through the RecC subunit to activate the nuclease domain of the RecB subunit.
    1. Structural Biology and Molecular Biophysics

    Structural basis for DNA 5´-end resection by RecJ

    Kaiying Cheng et al.
    A structural investigation reveals details of the mechanism by which the nuclease RecJ processes DNA ends to repair double strand breaks.

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