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A newly described isolate of the behavior-manipulating fly pathogen Entomophthora muscae that naturally infects fruit flies can be cultured in the lab, enabling molecular investigation of how microbes induce behavior changes in animal hosts.

Computational modeling combined with biophysical and cellular experiments reveal that rapid binding to incomplete, partial microtubule binding sites facilitates tracking of the end-binding protein EB1 with growing microtubule plus-ends.

Antitumor (natural killer) NK cell responses are negatively regulated by interactions between NK cells and endogenous NKG2D ligands constitutively expressed on lymph node endothelial cells and super-induced on tumor-associated endothelium.

Emotional learning retroactively promotes memory integration for previously neutral events into episodic memory to foster future event predictions, through rapidly stimulating trial-specific reactivation of overlapping memory traces and reorganization of associated memories among the amygdala, hippocampal, and neocortical circuits.

A combined theoretical and experimental study revealed the mechanistic and structural basis of mutational effects on allostery and provided insights into the intrinsic connection of intra- and inter-domain properties.

Positive feedback between contractile ring myosin and compression-driven cortical flow can explain the exponential accumulation of contractile ring components and constriction rate acceleration that ensures timely cell separation during cytokinesis.

Breast luminal epithelial cells are the hotspots of aging-associated changes, which prime aged epithelia for oncogenic gene activation and may explain individual differences in breast cancer susceptibility due to the aging-associated increase in gene expression variances in luminal epithelia.

Short-ranged and random connectivity are sufficient to explain complex, long-range activity patterns observed in macaque motor cortex that are, moreover, flexibly adaptable to behavior.

Combinatorial signaling leads to transcription factor co-localization at Rev-erb sensitive enhancers, enabling a diversified cellular response to complex stimuli.