86 results found
    1. Evolutionary Biology
    2. Genetics and Genomics

    Archaic introgression contributed to shape the adaptive modulation of angiogenesis and cardiovascular traits in human high-altitude populations from the Himalayas

    Giulia Ferraretti, Paolo Abondio ... Marco Sazzini
    A combination of composite-likelihood and gene network-based methods to investigate the impact of Denisovan introgression on the evolution of complex (i.e., polygenic) adaptive traits in high-altitude populations of Tibetan/Sherpa ancestry.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The evolutionary history of human spindle genes includes back-and-forth gene flow with Neandertals

    Stéphane Peyrégne, Janet Kelso ... Svante Pääbo
    Analyses of spindle genes with missense changes in modern humans reveal evidence for positive selection since the split with archaic humans and show that modern humans interacted with Neandertals more than once in the past 200,000 years.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Balancing selection on genomic deletion polymorphisms in humans

    Alber Aqil, Leo Speidel ... Omer Gokcumen
    The effect of balancing selection on the human genome is greater than previously appreciated, especially affecting large deletion variations.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Haplotypes spanning centromeric regions reveal persistence of large blocks of archaic DNA

    Sasha A Langley, Karen H Miga ... Charles H Langley
    Genomic polymorphism across centromeric regions of humans is organized into large-scale haplotypes with great diversity, including entire Neanderthal centromeres.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Detecting adaptive introgression in human evolution using convolutional neural networks

    Graham Gower, Pablo Iáñez Picazo ... Fernando Racimo
    Convolutional neural networks are an effective tool for detecting archaic adaptive introgression from genomic data.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The cis-regulatory effects of modern human-specific variants

    Carly V Weiss, Lana Harshman ... David Gokhman
    A genome-wide catalog of the regulatory effects of variants that separate modern humans from archaic humans.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Local adaptation and archaic introgression shape global diversity at human structural variant loci

    Stephanie M Yan, Rachel M Sherman ... Rajiv C McCoy
    Graph genotyping of structural variation in diverse human populations reveals functional associations and signatures of local adaptation within poorly resolved regions of the genome.
    1. Cell Biology
    2. Evolutionary Biology

    Genetic diversity of CHC22 clathrin impacts its function in glucose metabolism

    Matteo Fumagalli, Stephane M Camus ... Frances M Brodsky
    Natural selection shaped CHC22 clathrin genetic variation in humans with different diets and potentially influenced the human insulin response.
    1. Evolutionary Biology

    Homo naledi and Pleistocene hominin evolution in subequatorial Africa

    Lee R Berger, John Hawks ... Eric M Roberts
    A late Middle Pleistocene age for Homo naledi demonstrates a diversity of hominin species in Africa at this critical time in the archaeological record.

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