Mechanistic insight into the role of intranuclear Nup98 in gene expression is revealed by functional interactions with the helicase DHX9.

The newly developed antibody-free techniques, HepG4-seq for G-quadruplexes and HBD-seq for R-loops, robustly reveal the comprehensive maps of native G-quadruplexes and R-loops, as well as their roles in transcriptional regulation.

Tissue-specific transcription factors, such as basic motif leucine zipper protein NRL, interact with a plethora of RNA-binding proteins to perform pleiotropic functions during distinct steps of transcription process to generate quantitatively precise patterns of gene expression in neuronal cells.

A comparative approach shows that developmental evolution of neuropeptidergic neuronal groups in the hypothalamus of blind cavefish drives adaptive behavioral evolution.

The ES6S region of the small subunit ribosome makes a place for the threading and secondary structure unwinding of mRNA, which regulates genome-wide translation.

The distinct protein-RNA interactomes of HIV-1 RNA splice forms are revealed using a powerful multiplex strategy for RNA capture and mass spectrometric analysis.

Single-cell transcriptomics of the zebrafish ovary identifies both major and minor cell types and provides a valuable resource for researchers interested in reproductive biology, stem cell biology, and aquatic toxicology.

Proximity biotinylation of the Drosophila centromere suggests a role of RNA helicases, centromeric transcripts, and centromeric R-loops for centromere function.

Chemotherapeutics altering DNA topology evoke RNA polymerase I inhibition, rDNA damage and consequent formation of PNAs that segregate persistent rDNA lesions from the active nucleolus, with implications for rDNA maintenance and design of new cancer treatment strategies targeting rDNA repair.

An analysis of the genomic features that distinguish conserved from species-specific circular RNAs reveals that the expansion of the downstream intron by insertion of retrotransposons stabilizes circular RNAs' production across 30+ millions years of evolution.