18 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A RanGTP-independent mechanism allows ribosomal protein nuclear import for ribosome assembly

    Sabina Schütz, Ute Fischer ... Vikram G Panse
    The Tsr2 carrier protein connects the nuclear import machinery with the ribosome assembly pathway.
    1. Cell Biology

    A critical role for mTORC1 in erythropoiesis and anemia

    Zachary A Knight, Sarah F Schmidt ... Jeffrey M Friedman
    Transcription profiling of activated cells using Phospho-Trap, a new method for identifying activated cells, reveals a critical role for mTOR signaling in red blood cell development and the pathogenesis of anemia
    1. Developmental Biology
    2. Genetics and Genomics

    Cell competition removes segmental aneuploid cells from Drosophila imaginal disc-derived tissues based on ribosomal protein gene dose

    Zhejun Ji, Jacky Chuen ... Nicholas Baker
    Cell competition is an important mechanism selecting against aneuploid cells.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Haploinsufficiency of the essential gene Rps12 causes defects in erythropoiesis and hematopoietic stem cell maintenance

    Virginia Folgado-Marco, Kristina Ames ... Nicholas E Baker
    The homozygous and heterozygous phenotypes of mouse Rps12 deletion are described, highlighting pancytopenia reflecting roles in hematopoiesis and erythropoiesis.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Dedicated chaperones coordinate co-translational regulation of ribosomal protein production with ribosome assembly to preserve proteostasis

    Benjamin Pillet, Alfonso Méndez-Godoy ... Dieter Kressler
    A novel co-translational mechanism continuously adjusts the expression levels of ribosomal proteins Rpl3 and Rpl4 to their consumption during ribosome synthesis by regulating the abundance of their mRNAs.
    1. Developmental Biology

    Cell Competition: Counting the Minutes

    Stephano Mello, Dirk Bohmann
    A newly discovered mechanism that causes the 'Minute' phenotype in fruit flies can explain how organisms are able to eliminate the mutant cells that arise occasionally during development.
    Version of Record
    Insight
    1. Genetics and Genomics

    Gene-centric functional dissection of human genetic variation uncovers regulators of hematopoiesis

    Satish K Nandakumar, Sean K McFarland ... Vijay G Sankaran
    A gene-centric functional screen uncovers biological mechanisms underlying genome-wide association study signals for human red blood cell traits.
    1. Developmental Biology

    Erythropoietin signaling regulates heme biosynthesis

    Jacky Chung, Johannes G Wittig ... Barry H Paw
    EPO/JAK2/PKA signaling cascade via AKAP10 relocalization to the outer mitochondrial membrane results in the phosphorylation of the terminal heme synthesis enzyme ferrochelatase, which contributes to heme production in red cells.
    1. Biochemistry and Chemical Biology

    Cytosolic aspartate aminotransferase moonlights as a ribosome-binding modulator of Gcn2 activity during oxidative stress

    Robert A Crawford, Mark P Ashe ... Graham D Pavitt
    Using mass spectrometry to study protein composition of translating ribosomes under unstressed or stress conditions, aspartate aminotransferase 2 (Aat2) is identified as a metabolic enzyme with a moonlighting function in the yeast integrated stress-response pathway.
    1. Structural Biology and Molecular Biophysics

    Structures of translationally inactive mammalian ribosomes

    Alan Brown, Matthew R Baird ... Sichen Shao
    Mining electron cryomicroscopy data reveals new ribosomal interactions that preclude translation to potentially regulate gene expression.

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