81 results found
    1. Cell Biology

    ER-associated mitochondrial division links the distribution of mitochondria and mitochondrial DNA in yeast

    Andrew Murley et al.
    Sites at which mitochondria contact the endoplasmic reticulum co-localize the replication of mitochondria and their DNA to help ensure that DNA is distributed appropriately between the newly formed organelles in cells.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Cytoplasmic dynein crosslinks and slides anti-parallel microtubules using its two motor domains

    Marvin E Tanenbaum et al.
    The motor domains of dynein are sufficient to crosslink microtubules and slide them antiparallel to each other.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation

    Franziska Bleichert et al.
    Electron microscopy uncovers the structure of the origin recognition complex (ORC) in metazoans, and reveals how mutations in the ORC6 subunit lead to Meier-Gorlin syndrome in humans.
    1. Developmental Biology

    Developmental lineage priming in Dictyostelium by heterogeneous Ras activation

    Alex Chattwood et al.
    The probability of a cellular response to a differentiation inducing signal is correlated with the dynamic expression of a Ras protein, and produces a ‘salt and pepper’ pattern of cell differentiation.
    1. Developmental Biology

    Cell Fate Choice: Survival of the fattest

    Sophie M Morgani, Joshua M Brickman
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    1. Evolutionary Biology

    Regulated aggregative multicellularity in a close unicellular relative of metazoa

    Arnau Sebé-Pedrós et al.
    The transition to the aggregative stage of Capsaspora owczarzaki, a close unicellular relative to Metazoa, is associated with significant upregulation of orthologs of genes that are important for multicellularity in metazoans.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Small molecule-mediated refolding and activation of myosin motor function

    Michael B Radke et al.
    The small molecule EMD 57033 is one of a new class of pharmacological chaperones that stabilize, enhance the activity of, and correct stress-induced misfolding of myosin proteins.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Filament formation by metabolic enzymes is a specific adaptation to an advanced state of cellular starvation

    Ivana Petrovska et al.
    A starvation-induced drop in cytosolic pH promotes assembly of budding yeast glutamine synthetase into enzymatically inactive filaments that function as enzyme storage depots.
    1. Cell Biology
    2. Evolutionary Biology

    Vesicle Coat Proteins: Finding the missing link

    Thomas U Schwartz
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