92 results found
    1. Microbiology and Infectious Disease

    Toxoplasma TgATG9 is critical for autophagy and long-term persistence in tissue cysts

    David Smith et al.
    ATG9-dependent autophagy is an essential pathway for long-term survival within the cyst in the parasite Toxoplasma gondii and could be exploited in future studies seeking interventions against persistent Toxoplasma infection.
    1. Developmental Biology

    The LRR-TM protein PAN-1 interacts with MYRF to promote its nuclear translocation in synaptic remodeling

    Shi-Li Xia et al.
    Identified as a binding factor of transcription factor MYRF, the LRR-TM protein PAN-1 promotes the cell-membrane localization and nuclear translocation of MYRF, which drives synaptic rewiring in Caenorhabditis elegans.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    CM1-driven assembly and activation of yeast γ-tubulin small complex underlies microtubule nucleation

    Axel F Brilot et al.
    Cryo-EM structures reveal that the conserved CM1 motif drives γTuRC assembly by bridging adjacent γTuSC.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Molecular insights into substrate recognition and discrimination by the N-terminal domain of Lon AAA+ protease

    Shiou-Ru Tzeng et al.
    The N-terminal domains enable Lon protease to discriminate and capture selected protein species for degradation by exposed hydrophobic patches and flexible linkages to the hexameric core complex.
    1. Developmental Biology

    Spatiotemporal recruitment of RhoGTPase protein GRAF inhibits actomyosin ring constriction in Drosophila cellularization

    Swati Sharma, Richa Rikhy
    The RhoGTPase domain containing protein GRAF recruits to the cleavage furrow during myosin II assembly to hydrolyze Rho-GTP and restrict actomyosin contractility for regulating the time of onset of constriction during Drosophila cellularization.
    1. Developmental Biology
    2. Immunology and Inflammation

    Identification of functionally distinct macrophage subpopulations in Drosophila

    Jonathon Alexis Coates et al.
    Drosophila macrophages are a heterogeneous population of cells containing subpopulations with enhanced responses to injury that display considerable variation in their abundance across development.
    1. Developmental Biology
    2. Physics of Living Systems

    From local resynchronization to global pattern recovery in the zebrafish segmentation clock

    Koichiro Uriu et al.
    Theory explains how transport of gene expression vortices by cell advection may cause intermingled defective and normal segments along the body axis during resynchronization experiments in the zebrafish segmentation clock.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Evolutionary dynamics of transposable elements in bdelloid rotifers

    Reuben W Nowell et al.
    An investigation of transposable element evolution in a group of long-term asexual animals shows that many of the predicted effects of asexuality are not observed.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Mitochondrial copper and phosphate transporter specificity was defined early in the evolution of eukaryotes

    Xinyu Zhu et al.
    Ancient evolutionary signatures reveal mechanistic details of substrate specificity in copper-transporting mitochondria carrier family proteins.
    1. Cell Biology
    2. Evolutionary Biology

    A flagellate-to-amoeboid switch in the closest living relatives of animals

    Thibaut Brunet et al.
    The closest living relatives of animals, the choanoflagellates, switch from a flagellate to an amoeboid phenotype under confinement.

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