Adipose tissue derived hematopoietic stem cells from diabetic mice transplanted into healthy animals on a normal diet increase inflammation in adipose tissue and trigger the development of a diabetic state in the recipient animals.
The preoptic area (POA) regulates distinct metabolic adaptations, via leptin-dependent (fasting-induced hypometabolism and high-fat-diet-induced hypermetabolism), or leptin-independent mechanisms (temperature induced metabolic changes) and thus significantly contributes to body weight homeostasis.
Stimulation of endothelial glucose metabolism and vascular growth by genetic depletion of endothelial Foxo1 improves the whole-body response to a high-fat diet, by preserving adipose tissue functions and glucose homeostasis.
Aging is a process characterized by gradual metabolome remodeling, deceleration of the remodeling in late life and under conditions that extend lifespan, and a mortality-associated pattern of cumulative damage.
Hippocampome.org is an online resource that provides free human- and machine-readable access to the comprehensive property-based classification of hippocampal neurons from 14,000 pieces of published experimental evidence.