22 results found
    1. Developmental Biology

    Deficient spermiogenesis in mice lacking Rlim

    Feng Wang et al.
    Genetic analyses in mice identifies Rlim in the spermatogenic cell lineage as a regulator of cytoplasmic reduction during spermiogenesis.
    1. Neuroscience

    Learning-related population dynamics in the auditory thalamus

    Ariel Gilad et al.
    The auditory thalamus encodes higher-order information that emerges while learning an auditory discrimination task.
    1. Neuroscience

    Epigenetic inheritance of circadian period in clonal cells

    Yan Li et al.
    Global changes in gene expression associated with differential DNA methylation underlie epigenetic inheritance of circadian periodicity in cells.
    1. Neuroscience

    Mechanisms that allow cortical preparatory activity without inappropriate movement

    Timothy R Darlington, Stephen G Lisberger
    The use of preparatory activity in the smooth eye movement region of the frontal eye fields as a visual-motor gain signal allows preparation to progress without inappropriate movement.
    1. Computational and Systems Biology
    2. Neuroscience

    Sodium channels implement a molecular leaky integrator that detects action potentials and regulates neuronal firing

    Marco A Navarro et al.
    Kinetic interactions between sodium channels and auxiliary factors create a molecular computational engine that can sense and regulate cellular excitability.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    A genetic selection reveals functional metastable structures embedded in a toxin-encoding mRNA

    Sara Masachis et al.
    A genetic selection of toxicity suppressors coupled to high-throughput sequencing has captured metastable RNA structures that co-transcriptionally inhibit the translation of a bacterial toxin.
    1. Structural Biology and Molecular Biophysics

    Specific structural elements of the T-box riboswitch drive the two-step binding of the tRNA ligand

    Jiacheng Zhang et al.
    The glycine T-box riboswitch recognizes tRNAgly and senses its aminoacylation state by first interacting with the anticodon region and subsequently probing the 3' end of the ligand using both specific structural elements and conformational dynamics.
    1. Cell Biology

    CYK-4 functions independently of its centralspindlin partner ZEN-4 to cellularize oocytes in germline syncytia

    Kian-Yong Lee et al.
    The CYK-4 subunit of the broadly conserved intercellular bridge component centralspindlin, but not its ZEN-4 subunit, is essential for the cytokinesis-like closure of intercellular bridges that cellularizes oocytes to separate them from germline syncytia.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Incomplete inhibition of HIV infection results in more HIV infected lymph node cells by reducing cell death

    Laurelle Jackson et al.
    Under conditions where the force of HIV infection per cell is high, partial attenuation of infection with inhibitors can increase the number of live infected cells and may paradoxically be beneficial for viral spread.
  1. May roundup of eLife papers in the news

    Showcasing the top mentions that eLife papers received in May

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