Dispatched cleavage, mediated by Furin, regulates Dispatched membrane trafficking and release of Sonic Hedgehog ligand.

A composite hedgehog release model that incorporates and supports a previously disparate set of observations has been presented.

Sonic Hedgehog is transported inside cytonemes with co-receptors that promote contact-mediated signal delivery to initiate rapid, receptor-dependent responses in recipient cells.

PDGFRα+ Sca-1+ bone marrow stromal/stem cells in whole bone marrow grafts can trigger the onset of autoimmune-related fibrosis in a mouse model of scleroderma.

Biochemical and in planta studies reveal how a rice immune receptor pair has coevolved to deliver immune responses, an important step towards understanding and engineering bespoke resistance to crop pathogens that threaten food security.

Visualization of the sliding clamp in DNA mismatch repair shows how a transient complex is activated.

A software distributed platform for the Raspberry Pi to simplify and unify hardware access over the Ethernet network with almost real-time latencies.

A combined behavioural and electroencephalographic approach investigating the covert allocation of attention shows evidence for distributed periodic sampling away from a conscious visual image.

Intergenerational adaptations to stress play a critical role in organismal responses to changing environments and are largely lost or erased after one generation.