5,246 results found
    1. Cell Biology
    2. Developmental Biology

    Cytokine receptor-Eb1 interaction couples cell polarity and fate during asymmetric cell division

    Cuie Chen et al.
    A separation-of-function mutation reveals that a niche ligand receptor Dome functions in spindle orientation during asymmetric stem cell division by directly binding to Eb1, independent of its role in downstream JAK-STAT signaling.
    1. Neuroscience

    The Na+/Ca2+, K+ exchanger NCKX4 is required for efficient cone-mediated vision

    Frans Vinberg et al.
    Molecular, genetic, and functional analysis is used to show that the olfactory Na+/Ca2+, K+ exchanger NCKX4 is expressed in cone photoreceptors and is critical for the wide operating range and high temporal resolution of cone-mediated vision.
    1. Neuroscience

    Calcium dynamics regulating the timing of decision-making in C. elegans

    Yuki Tanimoto et al.
    A series of quantitative behavioural and opto-physiological analyses using a novel robot microscope system reveals that C. elegans computes the time-differential and time-integral of sensory information for decision-making during olfactory navigation.
    1. Microbiology and infectious disease

    Asymmetric division triggers cell-specific gene expression through coupled capture and stabilization of a phosphatase

    Niels Bradshaw, Richard Losick
    Asymmetric cell division is linked to cell-specific transcription by handoff of a key developmental regulator from the cytokinetic machinery to the adjacent cell pole where it oligomerizes to become stabilized and activated.
    1. Neuroscience

    How prior preferences determine decision-making frames and biases in the human brain

    Alizée Lopez-Persem et al.
    Model-based analyses of choice behavior and fMRI activity revealed that prior preferences generate default policies, which frame the decision value signal encoded in the vmPFC, and shift vmPFC pre-choice activity so as to induce a decision bias toward default options.
    1. Stem Cells and Regenerative Medicine

    Klp10A, a stem cell centrosome-enriched kinesin, balances asymmetries in Drosophila male germline stem cell division

    Cuie Chen et al.
    Microtubule-depolymerizing kinesin, Klp10A, prevents overgrowth of the mother centrosome to prevent undesirable asymmetries during asymmetric divisions of Drosophila male germline stem cells.
    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    A long non-coding RNA targets microRNA miR-34a to regulate colon cancer stem cell asymmetric division

    Lihua Wang et al.
    A novel long non-coding RNA targets microRNA miR-34a for epigenetic silencing and initiates asymmetric division of colon cancer stem cells.
    1. Neuroscience

    Cerebellar involvement in an evidence-accumulation decision-making task

    Ben Deverett et al.
    In a new evidence-accumulation decision-making task, activity of the lateral posterior cerebellum is necessary for accurate performance, and somatic and dendritic activity in Purkinje cells contains choice/evidence and error-related information.
    1. Cell Biology
    2. Developmental Biology

    Activation of Discs large by aPKC aligns the mitotic spindle to the polarity axis during asymmetric cell division

    Ognjen Golub et al.
    The Par complex controls spindle orientation during asymmetric cell division by phosphorylating the tumor suppressor Discs large, overcoming its autoinhibited state, and allowing it to bind the microtubule-binding protein GukHolder.
    1. Human Biology and Medicine
    2. Neuroscience

    A new motor synergy that serves the needs of oculomotor and eye lid systems while keeping the downtime of vision minimal

    Mohammad Farhan Khazali et al.
    Involuntary eye movements that keep images positioned over the center of the retina are synchronized with blinks to minimize disruption to vision.

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