1,083 results found
    1. Neuroscience

    TRPV4 overactivation enhances cellular contractility and drives ocular hypertension in TGFβ2 overexpressing eyes

    Christopher N Rudzitis, Monika Lakk ... David Križaj
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Convincing
    1. Biochemistry and Chemical Biology

    Alzheimer-mutant γ-secretase complexes stall amyloid β-peptide production

    Parnian Arafi, Sujan Devkota ... Michael S Wolfe
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    • Convincing
    1. Developmental Biology
    2. Neuroscience

    Aberrant FGF signaling promotes granule neuron precursor expansion in SHH subgroup infantile medulloblastoma

    Odessa R Yabut, Jessica Arela ... Samuel J Pleasure
    Mice with Suppressor of Fused mutations have aberrant cerebellar granule cell proliferation accompanied by ectopic expression of an FGF ligand, also expressed in infantile medulloblastoma patients.
    1. Chromosomes and Gene Expression

    Sir2 and Fun30 regulate ribosomal DNA replication timing via MCM helicase positioning and nucleosome occupancy

    Carmina Lichauco, Eric J Foss ... Antonio Bedalov
    Precocious ribosomal DNA replication in sir2 mutants requires Fun30.
    1. Structural Biology and Molecular Biophysics

    Wide Transition-State Ensemble as Key Component for Enzyme Catalysis

    Gabriel Ernesto Jara, Francesco Pontiggia ... Dorothee Kern
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Solid
    • Incomplete
    1. Developmental Biology

    Knockout of cyclin dependent kinases 8 and 19 leads to depletion of cyclin C and suppresses spermatogenesis and male fertility in mice

    Alexandra V Bruter, Ekaterina A Varlamova ... Victor V Tatarskiy
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Neuroscience

    An adaptable, reusable, and light implant for chronic Neuropixels probes

    Célian Bimbard, Flóra Takács ... Philip Coen
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Compelling
    1. Genetics and Genomics

    High-throughput tracking enables systematic phenotyping and drug repurposing in C. elegans disease models

    Thomas J O'Brien, Ida L Barlow ... André EX Brown
    High-throughput animal tracking and quantitative behaviour analysis detects diverse phenotypes in genetic disease models at a scale that makes drug screens possible.
    1. Neuroscience

    Drosulfakinin signaling encodes early-life memory for adaptive social plasticity

    Jiwon Jeong, Kujin Kwon ... Chunghun Lim
    Social clustering behaviors in Drosophila are closely tied to compensatory mechanisms for developmental traits and adaptive behavior plasticity, requiring early-life social experiences and the memory-encoding neuropeptide signaling pathway.

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