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    1. Neuroscience

    Single-cell transcriptomes of developing and adult olfactory receptor neurons in Drosophila

    Colleen N McLaughlin, Maria Brbić ... Hongjie Li
    Single-cell transcriptomes of olfactory receptor neurons at multiple developmental stages reveal cell-type-specific gene expression programs that underlie their development and sensory biology.
    1. Developmental Biology
    2. Evolutionary Biology

    Gene expression mapping of the neuroectoderm across phyla – conservation and divergence of early brain anlagen between insects and vertebrates

    Nico Posnien, Vera S Hunnekuhl, Gregor Bucher
    Hypotheses on brain homologies between insects and vertebrates are tested by comparing gene expression patterns from flies and beetles with those from vertebrates at early neuroectoderm stages.
    1. Stem Cells and Regenerative Medicine
    2. Neuroscience

    A functional genomics screen in planarians reveals regulators of whole-brain regeneration

    Rachel H Roberts-Galbraith, John L Brubacher, Phillip A Newmark
    A gene expression-guided functional screen identifies factors and cell types that regulate diverse aspects of neural regeneration in planarians.
    1. Neuroscience

    DIETS: a simple and sensitive assay to measure and control the intake of complex solid foods, like high-fat diets, in Drosophila

    Manikrao R. Thakare, Prerana Choudhary ... Gaurav Das
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Engineering paralog-specific PSD-95 recombinant binders as minimally interfering multimodal probes for advanced imaging techniques

    Charlotte Rimbault, Christelle Breillat ... Matthieu Sainlos
    Engineering new intrabodies allows to develop selective and non-interfering tools for the visualization of endogenous PSD-95 with advanced imaging techniques.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Transcriptional and epigenomic landscapes of CNS and non-CNS vascular endothelial cells

    Mark F Sabbagh, Jacob S Heng ... Jeremy Nathans
    Genome-wide integration of transcriptome, accessible chromatin, and DNA methylome data from vascular endothelial cells lays the foundation for understanding the gene regulatory circuits that generate organ-specific vascular specialization.
    1. Cell Biology
    2. Neuroscience

    Action potential-coupled Rho GTPase signaling drives presynaptic plasticity

    Shataakshi Dube O'Neil, Bence Rácz ... Scott H Soderling
    Proteomic and genetic analysis discovers a new cytoskeletal mechanism of presynaptic short-term plasticity common across neuronal cell types.
    1. Genetics and Genomics
    2. Neuroscience

    Molecular and spatial transcriptomic classification of midbrain dopamine neurons and their alterations in a LRRK2G2019S model of Parkinson’s disease

    Zachary Gaertner, Cameron Oram ... Rajeshwar Awatramani
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Plant Biology

    Unbiased proteomic and forward genetic screens reveal that mechanosensitive ion channel MSL10 functions at ER–plasma membrane contact sites in Arabidopsis thaliana

    Jennette M Codjoe, Ryan A Richardson ... Elizabeth S Haswell
    A mechanosensitive ion channel physically and genetically interacts with proteins that function at endoplasmic reticulum–plasma membrane contact sites.
    1. Neuroscience

    In silico analysis of the transcriptional regulatory logic of neuronal identity specification throughout the C. elegans nervous system

    Lori Glenwinkel, Seth R Taylor ... Oliver Hobert
    Neuron type-specific gene batteries share cis-regulatory motifs.