4,063 results found
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Chromocenters: Bundling up DNA

    Susan A Gerbi
    Structures known as chromocenters, comprising satellite DNA and proteins such as D1 or HMGA1, help to contain DNA inside the nucleus between cell divisions.
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    1. Biochemistry and Chemical Biology

    Intracellular Organization: Getting ready for DNA duplication

    Nina Y Yao, Michael E O'Donnell
    The discovery of a biomolecular condensate involved in DNA replication has wide ranging implications.
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    1. Chromosomes and Gene Expression

    Inter-Fork Strand Annealing causes genomic deletions during the termination of DNA replication

    Carl A Morrow et al.
    The discovery of a mechanism that causes DNA deletions during non-canonical DNA replication termination is described.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Diverse fates of uracilated HIV-1 DNA during infection of myeloid lineage cells

    Erik C Hansen et al.
    Uracil/adenine base pairs in HIV-1 DNA are attacked by the uracil base excision repair machinery in macrophages, which leads to HIV restriction and viral genome diversification by transcription-associated mutagenesis.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Opposing roles for DNA replication initiator proteins ORC1 and CDC6 in control of Cyclin E gene transcription

    Manzar Hossain, Bruce Stillman
    Two related DNA replication initiation proteins contribute to the decision of whether to enter a new round of the cell division cycle or enter into a period of proliferative quiescence.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    DNA methylation presents distinct binding sites for human transcription factors

    Shaohui Hu et al.
    A comprehensive study of human transcription factors reveals that a greater number of these proteins bind to methylated DNA sequences than previously thought.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A conserved MCM single-stranded DNA binding element is essential for replication initiation

    Clifford A Froelich et al.
    The crystal structure of the MCM helicase bound to single-stranded DNA reveals a binding motif that is critical for cell viability, helicase activation and DNA replication.
    1. Genetics and Genomics
    2. Plant Biology

    Contesting the presence of wheat in the British Isles 8,000 years ago by assessing ancient DNA authenticity from low-coverage data

    Clemens L Weiß et al.
    A computational method to authenticate low-coverage ancient DNA experiments shows that putative wheat sequences from 8000 years old sediments are most likely not of ancient origin.
    1. Chromosomes and Gene Expression

    Genomic DNA transposition induced by human PGBD5

    Anton G Henssen et al.
    The human PGBD5 gene encodes an active DNA transposase.
    1. Cell Biology

    DNA damage induces nuclear actin filament assembly by Formin-2 and Spire-1/2 that promotes efficient DNA repair

    Brittany J Belin et al.
    An efficient response to DNA damage requires the assembly of actin filaments in the nucleus.

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