171 results found
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Structure of dual BON-domain protein DolP identifies phospholipid binding as a new mechanism for protein localisation

    Jack Alfred Bryant et al.
    Analysis of the E. coli protein DolP reveals the first dual BON-domain structure and identifies phospholipid binding as a new mechanism for protein localisation to the outer membrane division site.
    1. Microbiology and Infectious Disease

    Lipoprotein DolP supports proper folding of BamA in the bacterial outer membrane promoting fitness upon envelope stress

    David Ranava et al.
    The envelope stress factor DolP associates with the outer membrane protein assembly machinery and supports proper folding and functioning of BamA contributing to preserve envelope integrity.
    1. Neuroscience

    Prediction Error: The expanding role of dopamine

    Bradley B Doll, Nathaniel D Daw
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    1. Neuroscience

    Instructed knowledge shapes feedback-driven aversive learning in striatum and orbitofrontal cortex, but not the amygdala

    Lauren Y Atlas et al.
    While the striatum and orbitofrontal cortex learn about threats through verbal warnings, the amygdala learns only from direct experience, suggesting that the amygdala forms part of a specialized threat detection system.
    1. Neuroscience

    High-fidelity musculoskeletal modeling reveals that motor planning variability contributes to the speed-accuracy tradeoff

    Mazen Al Borno et al.
    The speed-accuracy tradeoff could be a consequence of motor planning variability and not exclusively signal-dependent noise, as is currently held.
    1. Evolutionary Biology
    2. Plant Biology

    Origin and evolution of the nuclear auxin response system

    Sumanth K Mutte et al.
    The system that controls gene expression by the plant signaling molecule auxin has deep evolutionary roots, and stepwise increases in system complexity shaped the highly diverse auxin response in land plants.
    1. Cell Biology
    2. Developmental Biology

    Pentagone internalises glypicans to fine-tune multiple signalling pathways

    Mark Norman et al.
    Glypican proteins, required for morphogen signalling in Drosophila wing development, are endocytosed and degraded by the feedback regulator Pentagone.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Regenerative neurogenic response from glia requires insulin-driven neuron-glia communication

    Neale J Harrison et al.
    Neuronal Ia-2 and glial Kon coordinate an injury-response insulin relay that restores glial cell populations and induces neural stem cells from glia, enabling central nervous system regeneration.
    1. Developmental Biology
    2. Cell Biology

    Cells must express components of the planar cell polarity system and extracellular matrix to support cytonemes

    Hai Huang, Thomas B Kornberg
    Different cytoneme types require specific heparan sulfate proteoglycans (HSPGs) that are stratified within the extracellular matrix in Drosophila.
    1. Neuroscience

    Dopamine signaling tunes spatial pattern selectivity in C. elegans

    Bicheng Han et al.
    Natural variations in touch-dependent dopamine signaling tune the perception of spatial patterns in C. elegans.

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