The archaeal MCM helicase can load in multiple orientations on DNA but translocation proceeds with a leading N-terminal domain, which affects double hexamer activation at origins of replication.
Interviews with senior biomedical researchers reveal a perceived decline in trust in the scientific enterprise, in large part because the quantity of new data exceeds the field's ability to process it appropriately.
The way that bacteria grow—either floating in liquid or attached to a surface—affects their ability to evolve antimicrobial resistance and our ability to treat infections.
Early career researchers commonly peer review manuscripts on behalf of invited reviewers, often without receiving feedback or being named to the journal.