New technology for manipulating genes in Drosophila facilitates gene tagging and precise modification of virtually any gene.

The archaeal MCM helicase can load in multiple orientations on DNA but translocation proceeds with a leading N-terminal domain, which affects double hexamer activation at origins of replication.

Journals can benefit from listening to graduate students, postdocs and newly-independent group leaders.

Each stage of the scientific life cycle stands to benefit from the introduction of data science techniques.

Interviews with senior biomedical researchers reveal a perceived decline in trust in the scientific enterprise, in large part because the quantity of new data exceeds the field's ability to process it appropriately.

The way that bacteria grow—either floating in liquid or attached to a surface—affects their ability to evolve antimicrobial resistance and our ability to treat infections.

Early career researchers commonly peer review manuscripts on behalf of invited reviewers, often without receiving feedback or being named to the journal.

eLife is publishing a collection of articles and interviews with scientists who are parents to explore how to get the best of both worlds.