694 results found
    1. Neuroscience

    Alterations of in vivo CA1 network activity in Dp(16)1Yey Down syndrome model mice

    Matthieu Raveau et al.
    CA1 physiology is altered in the hippocampus of Down syndrome mice during both spatial exploration and rest, paralleled by an increase in populations of interneurons responsible for single cell and network synchronization.
    1. Neuroscience

    Alterations of specific cortical GABAergic circuits underlie abnormal network activity in a mouse model of Down syndrome

    Javier Zorrilla de San Martin et al.
    Distinct intrinsic excitability and synaptic dysfunctions in specific cortical inhibitory circuits lead to abnormal network activity in a mouse model of Down syndrome.
    1. Developmental Biology

    Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel

    Eva Lana-Elola et al.
    A panel of seven new mouse strains with chromosomal duplications is used to identify a minimal genetic region required in three copies to cause congenital heart defects typical of human Down syndrome.
    1. Genetics and Genomics

    A non-mosaic transchromosomic mouse model of Down syndrome carrying the long arm of human chromosome 21

    Yasuhiro Kazuki et al.
    TcMAC21 is an appropriate “next gen” mouse model for DS research, and provides a proof of concept of using artificial chromosomes to generate non-mosaic humanized animal models of chromosome disorders.
    1. Chromosomes and Gene Expression

    Trisomy 21 consistently activates the interferon response

    Kelly D Sullivan et al.
    Hyperactive interferon signaling is a hallmark of trisomy 21 and may contribute to many of the comorbidities associated with Down syndrome.
    1. Structural Biology and Molecular Biophysics

    Intraflagellar Transport: Moving proteins along in the cilium

    Narcis Adrian Petriman, Esben Lorentzen
    The structures of the bovine and human BBSome reveal that a conformational change is required to recruit the complex to the ciliary membrane.
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    1. Stem Cells and Regenerative Medicine

    Stem Cells: Put to the test

    Marites T Woon, Timothy J Kamp
    Personalized heart muscle cells made from stem cells in the laboratory could be used to check an individual’s response to potential new drugs before clinical trials.
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    1. Ecology
    2. Evolutionary Biology
    Zebrafish illustration

    The Natural History of Model Organisms: Advancing biology through a deeper understanding of zebrafish ecology and evolution

    David M Parichy
    The zebrafish is a premier model organism for biomedical research, with a rich array of tools and genomic resources, and combining these with a fuller appreciation of wild zebrafish ecology could greatly extend its utility in biological research.

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