The first genomic view of beetle luciferase evolution indicates evolutionary independence of luciferase between fireflies and click-beetles, and provide valuable datasets which will accelerate the discovery of new biotechnological tools.
Analysing developing mouse kidneys demonstrates nephron formation does not significantly impact branching morphogenesis of the ureteric bud, suggesting this process is distinct from branching in organs like the mammary gland.
The insect odorant receptor gene family evolved at the base of the class Insecta before the evolution of flight and perhaps as an adaptation to terrestriality, and was therefore an important evolutionary novelty for insects.
Chaperoning defects in axonemal dynein subunits trigger proteostatic clearance of dynein motors opening up the possibility of trialling proteostasis modulators to treat the motile ciliopathy primary ciliary dyskinesia (PCD).
During centrosome maturation, pericentrin is delivered to the centrosome co-translationally by a microtubule- and dynein-dependent process, as pericentrin mRNA is undergoing active translation near the centrosome.
Antitumor (natural killer) NK cell responses are negatively regulated by interactions between NK cells and endogenous NKG2D ligands constitutively expressed on lymph node endothelial cells and super-induced on tumor-associated endothelium.