2,855 results found
    1. Genetics and Genomics

    RETRACTED: Amino acid synthesis loss in parasitoid wasps and other hymenopterans

    Xinhai Ye, Shijiao Xiong ... Fei Li
    The synthesis capability of some amino acids is lost during the insect evolution, and hymenopteran parasitoids can make up for these deficiencies by altering free amino acid concentrations in host.
    1. Physics of Living Systems

    Active morphogenesis of patterned epithelial shells

    Diana Khoromskaia, Guillaume Salbreux
    An epithelium modelled as an active, nematic surface can display flattening, budding, and tubulation morphogenetic events, which are observed during development in biological organisms.
    1. Chromosomes and Gene Expression

    Dynamic spreading of chromatin-mediated gene silencing and reactivation between neighboring genes in single cells

    Sarah Lensch, Michael H Herschl ... Lacramioara Bintu
    In a synthetic system, spreading of chromatin-mediated silencing to nearby genes depends on distance and can bypass genetic insulators, while reactivation after release of gene targeting is coordinated by insulators and promoters.
    1. Neuroscience

    BehaviorDEPOT is a simple, flexible tool for automated behavioral detection based on markerless pose tracking

    Christopher J Gabriel, Zachary Zeidler ... Laura A DeNardo
    BehaviorDEPOT is a general purpose behavior analysis software that will meet the needs of thousands of behavioral neuroscientists who need accurate, flexible open-source software to analyze naturalistic behaviors and align then with neural data.
    1. Chromosomes and Gene Expression

    The S-phase-induced lncRNA SUNO1 promotes cell proliferation by controlling YAP1/Hippo signaling pathway

    Qinyu Hao, Xinying Zong ... Kannanganattu V Prasanth
    Cell cycle phase-specifically induced long non-coding RNAs regulate cell proliferation by modulating crucial cell signaling pathways.
    1. Cell Biology
    2. Neuroscience

    Endogenous hydrogen peroxide positively regulates secretion of a gut-derived peptide in neuroendocrine potentiation of the oxidative stress response in Caenorhabditis elegans

    Qi Jia, Drew Young ... Derek Sieburth
    Stress-regulated secretion of an intestinal peptide positively regulates the antioxidant response by promoting neuropeptide release from the nervous system, defining a gut-to-brain-to-gut endocrine axis in the oxidative stress response.
    1. Physics of Living Systems

    Mechanical instability and interfacial energy drive biofilm morphogenesis

    Jing Yan, Chenyi Fei ... Bonnie L Bassler
    Mechanical instabilities are shown to underlie the development of bacterial biofilm morphology, suggesting an ancient origin for mechano-morphogenesis, which is known to drive developmental processes in tissues in higher organisms.
    1. Developmental Biology
    2. Neuroscience

    Temporal analysis of enhancers during mouse cerebellar development reveals dynamic and novel regulatory functions

    Miguel Ramirez, Yuliya Badayeva ... Daniel Goldowitz
    An analysis of enhancer activity during mouse cerebellar development provides an invaluable resource for studying gene expression regulation by enhancers in the developing cerebellum and delivers a rich dataset of novel gene-enhancer associations providing a basis for future in-depth studies.
    1. Evolutionary Biology

    The skin microbiome facilitates adaptive tetrodotoxin production in poisonous newts

    Patric M Vaelli, Kevin R Theis ... Heather L Eisthen
    Skin-associated bacteria underlie the production of a potent defensive neurotoxin in newts, impacting host physiology, molecular evolution, and predator-prey interactions in a coevolutionary arms race.
    1. Plant Biology

    Decoys provide a scalable platform for the identification of plant E3 ubiquitin ligases that regulate circadian function

    Ann Feke, Wei Liu ... Joshua M Gendron
    The F-box and U-box E3 ubiquitin ligase decoy library is a powerful tool for the functional characterization of redundant E3 ubiquitin ligases, like MAC3A and MAC3B, novel circadian clock regulators.

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