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207 results found
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Dynamic turnover of centromeres drives karyotype evolution in Drosophila

    Ryan Bracewell et al.
    De novo formation of centromeres creates diverse karyotypes in flies and is accompanied by rapid turnover of centromere-associated satellite repeats.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    The life cycle of Drosophila orphan genes

    Nicola Palmieri et al.
    The short lifetime of orphan genes is a major factor explaining the stability of gene number in Drosophila.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Oxidative stress induces stem cell proliferation via TRPA1/RyR-mediated Ca2+ signaling in the Drosophila midgut

    Chiwei Xu et al.
    In response to tissue damage, reactive oxygen species can be sensed by cation channels TRPA1/RyR to cause increases of cytosolic Ca2+ in intestinal stem cells, activating Ras/MAPK activity and stimulating stem cell proliferation in Drosophila.
    1. Genetics and Genomics

    Firefly genomes illuminate parallel origins of bioluminescence in beetles

    Timothy R Fallon et al.
    The first genomic view of beetle luciferase evolution indicates evolutionary independence of luciferase between fireflies and click-beetles, and provide valuable datasets which will accelerate the discovery of new biotechnological tools.
    1. Cell Biology
    2. Neuroscience

    Tenectin recruits integrin to stabilize bouton architecture and regulate vesicle release at the Drosophila neuromuscular junction

    Qi Wang et al.
    Characterization of Tnc as a selective integrin ligand at the Drosophila NMJ allows for unprecedented insights into our understanding of extracellular matrix/integrin interactions at synaptic locations and reveals novel, distinct presynaptic and postsynaptic integrin functions.
    1. Cell Biology
    2. Neuroscience

    Reconstruction of genetically identified neurons imaged by serial-section electron microscopy

    Maximilian Joesch et al.
    A new pipeline of electron microscopy techniques reduces the time required to visualize genetically targeted neurons and their connections by two orders of magnitude.
    1. Cell Biology
    2. Developmental Biology

    Novel functions for integrin-associated proteins revealed by analysis of myofibril attachment in Drosophila

    Hannah J Green et al.
    Integrin and actin associated proteins are resolved into four layers within myofibril attachments, an architecture requiring balanced positive and negative regulation of integrin adhesion with integrated mechanotransduction and actin pathways.
    1. Cell Biology
    2. Developmental Biology

    The Drosophila formin Fhos is a primary mediator of sarcomeric thin-filament array assembly

    Arkadi Shwartz et al.
    Actin is incorporated into the thin-filament arrays of skeletal muscle sarcomeres in discrete steps, and Fhos, the Drosophila homolog of FHOD-family formins, is an essential player in the process.
    1. Evolutionary Biology
    2. Neuroscience

    Divergent sensory investment mirrors potential speciation via niche partitioning across Drosophila

    Ian W Keesey et al.
    Phototaxis and courtship behavioral preferences reflect strong correlation with differences in olfactory and visual nervous system investment across five monophyletic Drosophila species, and could help explain their speciation events.
    1. Cell Biology
    2. Developmental Biology

    The ESCRT machinery regulates retromer-dependent transcytosis of septate junction components in Drosophila

    Hendrik Pannen et al.
    A novel role of endosomal machineries retromer and ESCRT in membrane delivery of Drosophila septate junction components is required for maintenance of junction integrity and epithelial barrier function.

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