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    1. Evolutionary Biology
    2. Genetics and Genomics

    Expansion and loss of sperm nuclear basic protein genes in Drosophila correspond with genetic conflicts between sex chromosomes

    Ching-Ho Chang, Isabel Mejia Natividad, Harmit S Malik
    Genetic conflicts between sex chromosomes during spermatogenesis may drive the rapid evolution, function, and turnover of some sperm nuclear basic proteins in Drosophila species.
    1. Stem Cells and Regenerative Medicine

    Reactive oxygen species-dependent Toll/NF-κB activation in the Drosophila hematopoietic niche confers resistance to wasp parasitism

    Isabelle Louradour, Anurag Sharma ... Nathalie Vanzo
    In the Drosophila hematopoietic microenvironment, a regulatory network involving Toll/NF-B, EGFR signaling and reactive oxygen species controls blood cell production in response to immune stress.
    1. Cell Biology
    2. Developmental Biology

    Duox-generated reactive oxygen species activate ATR/Chk1 to induce G2 arrest in Drosophila tracheoblasts

    Amrutha Kizhedathu, Piyush Chhajed ... Arjun Guha
    Reactive oxygen species can activate the ATR/Chk1 pathway in the absence of detectable DNA damage and without a requirement for DNA damage response proteins.
    1. Developmental Biology

    Notch signaling and Bsh homeodomain activity are integrated to diversify Drosophila lamina neuron types

    Chundi Xu, Tyler B Ramos ... Chris Q Doe
    Notch signaling specifies binary neuronal fates through its integration with primary homeodomain activity.
    1. Ecology
    Drosophila illustration

    The Natural History of Model Organisms: The secret lives of Drosophila flies

    Therese Ann Markow
    After decades of intensive research, D. melanogaster and its relatives could provide important tools for investigating future biological questions about human health and environmental change, but only if we better understand their natural history.
    1. Developmental Biology
    2. Neuroscience

    Neuroblast-specific open chromatin allows the temporal transcription factor, Hunchback, to bind neuroblast-specific loci

    Sonia Q Sen, Sachin Chanchani ... Chris Q Doe
    Spatial factors generate neuroblast-specific open chromatin, thereby biasing the subsequent binding of transcription factors to produce neuroblast-specific neurons.
    1. Ecology
    2. Neuroscience

    Dopamine drives Drosophila sechellia adaptation to its toxic host

    Sofía Lavista-Llanos, Aleš Svatoš ... Bill S Hansson
    The insect dopaminergic system serves an important function in the regulation of ontogenesis and early development, contributing to the evolutionary processes that limit the ecological niche of Drosophila sechellia.
    1. Cell Biology
    2. Developmental Biology

    The NDNF-like factor Nord is a Hedgehog-induced extracellular BMP modulator that regulates Drosophila wing patterning and growth

    Shu Yang, Xuefeng Wu ... Xiaoyan Zheng
    The NDNF-like factor Nord is a Hedgehog-induced and extracellular-localized dosage-dependent BMP modulator that regulates Drosophila wing patterning and growth.
    1. Neuroscience

    Global change in brain state during spontaneous and forced walk in Drosophila is composed of combined activity patterns of different neuron classes

    Sophie Aimon, Karen Y Cheng ... Ilona C Grunwald Kadow
    Major neuron classes are activated when the fly walks, whether it chooses or is forced to do so.
    1. Evolutionary Biology
    2. Neuroscience

    Divergent sensory investment mirrors potential speciation via niche partitioning across Drosophila

    Ian W Keesey, Veit Grabe ... Bill S Hansson
    Phototaxis and courtship behavioral preferences reflect strong correlation with differences in olfactory and visual nervous system investment across five monophyletic Drosophila species, and could help explain their speciation events.