1,017 results found
    1. Neuroscience

    A kinase-dependent feedforward loop affects CREBB stability and long term memory formation

    Pei-Tseng Lee et al.
    Through an image and behavioral screen based on MiMIC technology, we identified a novel kinase, CG11221 renamed Meng-Po (MP), and showed that flies that lack MP in mushroom bodies can learn but cannot remember as MP is required for the protein stability of CREBB.
    1. Developmental Biology and Stem Cells

    CtBP impedes JNK- and Upd/STAT-driven cell fate misspecifications in regenerating Drosophila imaginal discs

    Melanie I Worley et al.
    The CtBP protein stabilizes cell fates in regenerating tissue.
    1. Cell Biology

    GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells

    Marina Besprozvannaya et al.
    Functionally distinct ER-PM domains in human cells are defined by conserved GRAM domain containing proteins.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Translational control of ERK signaling through miRNA/4EHP-directed silencing

    Seyed Mehdi Jafarnejad et al.
    ERK/MAPK activity is regulated by the cap-binding protein 4EHP, via translational control of the DUSP6 phosphatase.
    1. Biophysics and Structural Biology

    Conserved conformational selection mechanism of Hsp70 chaperone-substrate interactions

    Ashok Sekhar et al.
    NMR-based flux measurements show that both bacterial and human Hsp70 chaperones interact with helical, as well as sheet substrates predominantly through a conformational selection mechanism.
    1. Neuroscience

    Role of the visual experience-dependent nascent proteome in neuronal plasticity

    Han-Hsuan Liu et al.
    A screen of visual-experience induced changes in newly-synthesized proteins in Xenopus optic tectum identifies unexpected candidate plasticity proteins.
    1. Cancer Biology

    Targeting posttranslational modifications of RIOK1 inhibits the progression of colorectal and gastric cancers

    Xuehui Hong et al.
    A Methylation-Phosphorylation Switch Determines RioK1 Stability and Function in CRC and GC Progression.
    1. Genes and Chromosomes

    MukB ATPases are regulated independently by the N- and C-terminal domains of MukF kleisin

    Katarzyna Zawadzka et al.
    In Escherichia coli structural maintenance of chromosomes (SMC) complex, MukBEF, a dimeric MukF kleisin binds and activates MukB SMC ATPases through two independent interfaces provided by distinct MukF N- and C-terminal domains.
    1. Neuroscience

    Internal amino acid state modulates yeast taste neurons to support protein homeostasis in Drosophila

    Kathrin Steck et al.
    Two different classes of taste receptor neurons in the Drosophila melanogaster proboscis play distinct roles in yeast feeding and are both modulated by the fly's internal amino acid state in order to promote protein-specific appetite.
    1. Developmental Biology and Stem Cells

    Transgenerational dynamics of rDNA copy number in Drosophila male germline stem cells

    Kevin L Lu et al.
    rDNA copy number is shown to dynamically change during aging and through generations, and is actively maintained in male germline of Drosophila.

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