3,256 results found
    1. Developmental Biology
    2. Physics of Living Systems

    From local resynchronization to global pattern recovery in the zebrafish segmentation clock

    Koichiro Uriu, Bo-Kai Liao ... Luis G Morelli
    Theory explains how transport of gene expression vortices by cell advection may cause intermingled defective and normal segments along the body axis during resynchronization experiments in the zebrafish segmentation clock.
    1. Physics of Living Systems

    Hydrodynamics and multiscale order in confluent epithelia

    Josep-Maria Armengol-Collado, Livio Nicola Carenza, Luca Giomi
    Confluent cellular layers display the remarkable ability of supportingmultiscale orientational order, that is the existence of different typeof liquid crystal order at different length scales.
    1. Neuroscience

    Control of innate olfactory valence by segregated cortical amygdala circuits

    James R Howe, Chung-Lung Chan ... Cory M Root
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Analyzing the brainstem circuits for respiratory chemosensitivity in freely moving mice

    Amol Bhandare, Joseph van de Wiel ... Nicholas Dale
    Recordings from brainstem nuclei involved in chemosensory regulation of breathing in awake freely behaving mice show different complementary types of neuronal responses to hypercapnia in the retrotrapezoid nucleus and the rostral medullary raphe.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Analysis of CDPK1 targets identifies a trafficking adaptor complex that regulates microneme exocytosis in Toxoplasma

    Alex W Chan, Malgorzata Broncel ... Sebastian Lourido
    Comprehensive characterization of kinase-dependent phosphorylation in the human pathogen Toxoplasma gondii identifies a trafficking adaptor complex required for virulence factor secretion and infection.
    1. Neuroscience

    FluoEM, virtual labeling of axons in three-dimensional electron microscopy data for long-range connectomics

    Florian Drawitsch, Ali Karimi ... Moritz Helmstaedter
    Methodology to annotate the multiple origins of axonal projections in dense electron microscopy data of mammalian nervous tissue without the need of chemical label conversion is reported.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Dedicated chaperones coordinate co-translational regulation of ribosomal protein production with ribosome assembly to preserve proteostasis

    Benjamin Pillet, Alfonso Méndez-Godoy ... Dieter Kressler
    A novel co-translational mechanism continuously adjusts the expression levels of ribosomal proteins Rpl3 and Rpl4 to their consumption during ribosome synthesis by regulating the abundance of their mRNAs.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Highly regulated, diversifying NTP-dependent biological conflict systems with implications for the emergence of multicellularity

    Gurmeet Kaur, A Maxwell Burroughs ... L Aravind
    Multicellular and socially aggregating prokaryotes contain previously undescribed, chaperone-based systems predicted to mediate defensive biological conflicts, several components of which are thematically similar antecedents of eukaryotic apoptosis pathways.
    1. Developmental Biology
    2. Neuroscience

    Expansion microscopy of C. elegans

    Chih-Chieh (Jay) Yu, Nicholas C Barry ... Edward S Boyden
    Fixed, intact animals of C. elegans can be physically expanded with high isotropy, to enable super-resolved imaging of general proteins and nucleic acids throughout the organism, on conventional microscopes.

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