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    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Pooled genome-wide CRISPR screening for basal and context-specific fitness gene essentiality in Drosophila cells

    Raghuvir Viswanatha et al.
    Pooled CRISPR knockout screening in Drosophila cells enables high-resolution, genome-wide functional genomic comparisons in cell-lines across vast evolutionary distance.
    1. Developmental Biology

    aPKC-mediated displacement and actomyosin-mediated retention polarize Miranda in Drosophila neuroblasts

    Matthew Robert Hannaford et al.
    The actomyosin network and phospho-regulation combine to polarize fate determinants at the Drosophila neuroblast cell cortex.
    1. Cell Biology

    Stress-induced Cdk5 activity enhances cytoprotective basal autophagy in Drosophila melanogaster by phosphorylating acinus at serine437

    Nilay Nandi et al.
    Cdk5-mediated stabilization of Acinus in postmitotic neurons promotes autophagy and the removal of protein aggregates linked to neurodegeneration in Drosophila melanogaster.
    1. Stem Cells and Regenerative Medicine

    Reactive oxygen species-dependent Toll/NF-κB activation in the Drosophila hematopoietic niche confers resistance to wasp parasitism

    Isabelle Louradour et al.
    In the Drosophila hematopoietic microenvironment, a regulatory network involving Toll/NF-B, EGFR signaling and reactive oxygen species controls blood cell production in response to immune stress.
    1. Stem Cells and Regenerative Medicine

    Dpp dependent Hematopoietic stem cells give rise to Hh dependent blood progenitors in larval lymph gland of Drosophila

    Nidhi Sharma Dey et al.
    Identification of Hematopoietic stem cells (HSCs) in the genetically amenable organism Drosophila melanogaster paves the path to address HSC biology, both in normal and pathophysiological conditions.
    1. Cell Biology
    2. Developmental Biology

    Plasticity of both planar cell polarity and cell identity during the development of Drosophila

    Pedro Saavedra et al.
    In the Drosophila larval epidermis both the cell identity and polarity of individual cells change as a result of cell rearrangements.
    1. Computational and Systems Biology
    2. Neuroscience

    Automated analysis of long-term grooming behavior in Drosophila using a k-nearest neighbors classifier

    Bing Qiao et al.
    Drosophila grooming is driven by two internal programs.
    1. Chromosomes and Gene Expression

    Conserved noncoding transcription and core promoter regulatory code in early Drosophila development

    Philippe J Batut, Thomas R Gingeras
    Gene expression timing during Drosophila development is specified by multiple classes of RNA polymerase II core promoters, and the embryonic transcriptome includes thousands of evolutionarily conserved long noncoding RNAs.
    1. Neuroscience

    Cellular diversity in the Drosophila midbrain revealed by single-cell transcriptomics

    Vincent Croset et al.
    Sequencing mRNA from thousands of single cells from the Drosophila brain highlights the extent of cellular diversity and reveals co-expression of specific neuropeptides with particular fast-acting neurotransmitters and monoamines.
    1. Developmental Biology
    2. Genetics and Genomics

    A genome-wide resource for the analysis of protein localisation in Drosophila

    Mihail Sarov et al.
    A large-scale transgenic resource enables live imaging, subcellular localisation and interaction proteomics of specific gene products of interest at all stages of Drosophila development.