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Genetics and Genomics
A genome-wide resource for the analysis of protein localisation in
Mihail Sarov et al.
A large-scale transgenic resource enables live imaging, subcellular localisation and interaction proteomics of specific gene products of interest at all stages of
The metal transporter ZIP13 supplies iron into the secretory pathway in
Guiran Xiao et al.
ZIP13 (Slc39a13), a presumed zinc importer, is responsible for iron delivery to the secretory pathway.
Differential regulation of the
sleep homeostat by circadian and arousal inputs
Jinfei D Ni et al.
Functional imaging and circuit mapping in the
brain identifies neuropils where sleep-promoting and arousal-promoting neuronal networks converge.
Computational and Systems Biology
Automated analysis of long-term grooming behavior in
-nearest neighbors classifier
Bing Qiao et al.
Drosophila grooming is driven by two internal programs.
Chromosomes and Gene Expression
Conserved noncoding transcription and core promoter regulatory code in early
Philippe J Batut, Thomas R Gingeras
Gene expression timing during
development is specified by multiple classes of RNA polymerase II core promoters, and the embryonic transcriptome includes thousands of evolutionarily conserved long noncoding RNAs.
Neuronal processing of noxious thermal stimuli mediated by dendritic Ca
Shin-Ichiro Terada et al.
polymodal nociceptors use precipitous fluctuation of the firing rate, which depends on Ca
influx, as a key signal encoding a heat sensation and evoking the robust heat avoidance behavior.
Sweet neurons inhibit texture discrimination by signaling TMC-expressing mechanosensitive neurons in
Shun-Fan Wu et al.
use distinct sensory mechanisms to detect and integrate the same tactile and taste information in two decision-making tasks that serve two different purposes.
Single cell transcriptome atlas of the
Clarisse Brunet Avalos et al.
Single-cell transcriptomics identifies cellular composition of the first instar
brain and the response to starvation.
Molecular basis of fatty acid taste in
Ji-Eun Ahn et al.
Molecular-genetic, neural imaging and behavioral analyses reveal how Drosophila melanogaster sense fatty acids, important nutrient compounds, through multimeric Ionoptropic Receptors complexes.
Atg9 antagonizes TOR signaling to regulate intestinal cell growth and epithelial homeostasis in
Jung-Kun Wen et al.
Atg9 inhibits TOR signaling to regulate cell growth and tissue homeostasis in
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