Social clustering behaviors in Drosophila are closely tied to compensatory mechanisms for developmental traits and adaptive behavior plasticity, requiring early-life social experiences and the memory-encoding neuropeptide signaling pathway.

Prothoracicotropic hormone and ecdysone belonging to the insect PG axis modulate virgin female sexual receptivity.

Connectomic, optogenetic, and high-throughput behavioral analyses identify a descending neuron in the fruit fly larval brain that modifies the timing of nociception-induced rolling.

The newly characterized activity regulating neuropeptide encoding gene Spar is a transcriptional target of the Jeb/Alk receptor tyrosine kinase signaling pathway in the Drosophila nervous system.

Descending inhibition of nociception from the brain has been identified in Drosophila larvae, for the first time in non-mammalian organisms.

A single-cell RNA-seq study examining gene expression profiles in neurons that underlie Drosophila reproductive behaviors shows males and females build sex-specific behaviors at the molecular-genetic level by overlaying sex-specific information on core gene expression networks.

The neuropeptide Drosulfakinin (DSK) functions in a subset of DSK neurons to interact with neural nodes in the sex circuit and acts through its receptor CCKLR-17D3 to control female sexual behavior.