146 results found
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Rapid and iterative genome editing in the malaria parasite Plasmodium knowlesi provides new tools for P. vivax research

    Franziska Mohring et al.
    Optimised genome editing in P. knowlesi enables transgenic expression of a lead P. vivax vaccine candidate, revealing roles in host cell tropisms and providing tools for scalable vaccine efficacy testing.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells

    Karmel A Allison et al.
    Pre-existing enhancers interpret T cell signaling strength in an analogue manner to direct quantitative changes in gene expression within the context of an overall digital response.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Common virulence gene expression in adult first-time infected malaria patients and severe cases

    J Stephan Wichers et al.
    Parasites with pathogenic variant surface antigens are common in adult malaria patients with a naive immune status.
    1. Neuroscience

    Flexible motor sequence generation during stereotyped escape responses

    Yuan Wang et al.
    Time-ordered and flexible motor sequences in C.elegans are generated by combining an excitatory feedforward coupling and mutual inhibitions between neurons in different functional modules.
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    Two bifunctional inositol pyrophosphate kinases/phosphatases control plant phosphate homeostasis

    Jinsheng Zhu et al.
    Genetic and biochemical analysis of two enzymes reveals that inositol pyrophosphate signaling molecules allow plants to sense and regulate cellular phosphate levels, and to take up more phosphate when needed.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    A fusion peptide in preS1 and the human protein disulfide isomerase ERp57 are involved in hepatitis B virus membrane fusion process

    Jimena Pérez-Vargas et al.
    The mechanism triggering HBV membrane fusion involves ERp57, a cellular protein disulfide isomerase, and ultimately leads to the exposition of a fusion peptide that was identified in the pre-S1 determinant.
    1. Cell Biology
    2. Computational and Systems Biology

    Science Forum: The Human Cell Atlas

    Aviv Regev et al.
    Advances in techniques for analysing single cells and tissues have inspired an international effort to create comprehensive reference maps of all human cells - the fundamental units of life - as a basis for both understanding human health and diagnosing, monitoring and treating disease.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Virus Evolution: A new twist in measuring mutation rates

    Bartram L Smith, Claus O Wilke
    The influenza virus mutates faster than we previously thought.
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    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structures of diverse poxin cGAMP nucleases reveal a widespread role for cGAS-STING evasion in host–pathogen conflict

    James B Eaglesham et al.
    Poxin enzymes are a diverse family of insect and viral 2′3′-cGAMP nucleases, which evolved from self-cleaving RNA virus accessory proteases.
    1. Cell Biology
    2. Immunology and Inflammation

    Convalescent COVID-19 patients are susceptible to endothelial dysfunction due to persistent immune activation

    Florence WJ Chioh et al.
    COVID-19 survivors, who are at risk for vascular complications, would benefit from close monitoring and preventive therapy.

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