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Zebrafish genetics and sperm cryo-electron tomography reveal a novel function of Calaxin as a docking complex component stabilizing the outer arm dynein onto the ciliary doublet microtubule.

A pair of microtubules, ensembles of oppositely oriented axonemal dyneins, and inter-microtubule crosslinkers are the minimum components needed for oscillation and repetitive bending motions.

Using a proximity-dependent labeling approach in living cells, the human cytoplasmic dynein-1 interactome was identified and a new family of dynein activators, ninein and ninein-like, was discovered.

The combinatorial assembly of different adaptor complexes is a mechanism that dynein uses to interact with multiple cargos.

KASH5 uses an EF-hand domain to directly interact with the light intermediate chain of dynein, promotes processive dynein motility, and facilitates dynein recruitment to the nuclear envelope during prophase I of meiosis.

Kazrin, a protein widely expressed in vertebrates whose depletion causes defects in cell adhesion and migration, is recruited to early endosomes and promotes dynein/dynactin-dependent traffic of endocytosed cargo to the recycling endosomes.

At mitosis, NuMA recruits dynein-dynactin to microtubule minus-ends, enabling robust microtubule clustering and the emergence of spindle poles.

The glial developmental factor, Daam2, promotes glioma tumorigenesis by degrading the VHL tumor suppressor, illustrating how dysregulation of gliogenic factors can impact tumor suppressor activity and promote glioma tumorigenesis.

Dynein-dependent microtubule-cortex interactions – "side-on" versus "end-on" pulling – are regulated by cortical ER and mediated by distinct pools of cortical anchor that are differentially localized along the cell periphery.

Cortical dynein organizes unipolar microtubule arrays in Drosophila axons by expelling minus-end-out microtubules.