Polarity cascade initiated by aPKC in the periderm is transduced by adherens junction component E-cadherin to the basal epidermis during the development of zebrafish bilayered epidermis.

Two critical events initiate and promote efficient desmosome assembly: stable binding of opposing E-cadherin cell-cell adhesion proteins; and direct interaction of E-cadherin and Desmoglein.

The primary molecular mechanosensor involved in a physiological process of mechanically induced cell fate differentiation is revealed here for the first time in vivo, highly sensitive and potentially shared by all metazoan epithelia.

From middle childhood to early adulthood, the preference to engage with novel choice options remained consistent, but aversion to reward uncertainty increased.

Genetic and functional manipulations uncover urocortin-3-expressing neurons in the perifornical area of the hypothalamus as a dedicated circuit component for the expression of infant-directed neglect and aggression in mice.

A discrete group of interconnected neurons are shown to drive aggressive social interactions in Drosophila females and genetic tools to manipulate these neuronal cell types are provided.

The differentiation decisions made by pluripotent cells depend on their exposure to appropriate extrinsic signals and also on morphogenetic events that control receptivity to those differentiation cues.

A combined experimental and computational approach was developed to understand lateral interactions between membrane-bound proteins and used to quantify the contributions of specific and non-specific interactions to cadherin cis-binding kinetics.

Cell movement toward and away from the midline of an epithelium over tens of hours are caused by spontaneous or externally-applied shear forces to eliminate force imbalances within the tissue.

The transcription factor, MEF2C, mediates a change in approximately one half of the expressed frontal cortical transcriptome controlling cellular metabolism and synaptic strength in response to acute loss of sleep.