3,311 results found
    1. Cancer Biology
    2. Developmental Biology and Stem Cells

    A metabolic switch controls intestinal differentiation downstream of Adenomatous polyposis coli (APC)

    Imelda T Sandoval et al
    The tumor suppressor APC regulates a metabolic program that drives normal intestinal differentiation in zebrafish.
    Research Article
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    1. Ecology
    2. Genomics and Evolutionary Biology
    3. Microbiology and Infectious Disease

    The Natural History of Model Organisms: The unexhausted potential of E. coli

    Zachary D Blount
    A better understanding of the remarkable diversity, natural history and complex ecology of E. coli in the wild could shed new light on its biology and role in disease, and further expand its many uses as a model organism.
    Feature Article
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    1. Biochemistry
    2. Biophysics and Structural Biology

    Structural basis of transcription arrest by coliphage HK022 Nun in an Escherichia coli RNA polymerase elongation complex

    Jin Young Kang et al
    Cryo-electron microscopy structures show how coliphage HK022 Nun blocks Escherichia coli RNA polymerase translocation by mediating multiple interactions between the RNA polymerase and nucleic acids.
    Research Article Updated
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    1. Biophysics and Structural Biology

    Structural dynamics of E. coli single-stranded DNA binding protein reveal DNA wrapping and unwrapping pathways

    Sukrit Suksombat et al
    Single-molecule force and fluorescence spectroscopy reveal the structural states and dynamics of E. coli single-stranded DNA binding proteins and the energy landscape of the nucleo–protein complex.
    Research Article Updated
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    1. Microbiology and Infectious Disease

    Factors essential for L,D-transpeptidase-mediated peptidoglycan cross-linking and β-lactam resistance in Escherichia coli

    Jean-Emmanuel Hugonnet et al
    Production of the L,D-transpeptidase YcbB and elevated synthesis of the (p)ppGpp alarmone reveals a new mode of peptidoglycan polymerization that bypasses the D,D-transpeptidase activity of PBPs and leads to broad-spectrum β-lactam resistance in Escherichia coli.
    Research Article Updated
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    1. Genomics and Evolutionary Biology

    RNA chaperones buffer deleterious mutations in E. coli

    Marina Rudan et al
    The overexpression of RNA chaperones, including several DEAD box RNA helicases, enhances the fitness of mutationally compromised E. coli strains.
    Research Article Updated
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    1. Microbiology and Infectious Disease

    A mutant Escherichia coli that attaches peptidoglycan to lipopolysaccharide and displays cell wall on its surface

    Marcin Grabowicz et al
    A single mutation in Escherichia coli connects two essential cell envelope assembly pathways and confers vancomycin resistance by displaying molecular decoys at the cell surface.
    Short Report Updated
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    1. Biophysics and Structural Biology
    2. Microbiology and Infectious Disease

    Escherichia coli swimming is robust against variations in flagellar number

    Patrick J Mears et al
    The swimming behavior of E. coli is surprisingly robust against the natural variations in the number of flagella per cell.
    Research Article
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    1. Biophysics and Structural Biology

    Cryo-EM structures of the autoinhibited E. coli ATP synthase in three rotational states

    Meghna Sobti et al
    A molecular model that provides a framework for interpreting the wealth of functional information obtained on the E. coli F-ATP synthase has been generated using cryo-electron microscopy.
    Research Article Updated
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    1. Biophysics and Structural Biology

    Assembly principles of a unique cage formed by hexameric and decameric E. coli proteins

    Hélène Malet et al
    Cryo-electron microscopy uncovers molecular determinants of a unique symmetry mismatched macromolecular cage in E. coli.
    Research Article Updated
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