In vivo inhibition of SUMO activating E1-enzymes by pyrophosphate reveals a mode of integrating metabolism and stress tolerance that is conserved across kingdoms.

Shigella infection induces a calpain-mediated loss of SUMO conjugates that promotes bacterial entry.

Co-evolving residue pairs in the different components of a protein complex almost always make contact across the protein–protein interface, thus providing powerful restraints for the modeling of protein complexes.

A genetic mutation that impairs autophagic flux leads to neurodegeneration and can cause ataxia and developmental delay in children.

Aberrant neddylation of non-cullin substrates disrupts normal cell cycle progression.

β-arrestins recruit Nedd4 ubiquitin E3 ligase to mGlu7 receptor and facilitate ubiquitination, endocytosis, ERK signaling, and stability of mGlu7 at presynaptic terminals.

Activation of the sarcoplasmic reticulum calcium pump and enhancement of cellular calcium homeostasis by dwarf open reading frame reveal how this small membrane protein opposes phospholamban inhibitory function in cardiac muscle.

The cancer-associated human ubiquitin ligase HUWE1 can adopt an auto-inhibited dimeric state, whose occupancy is regulated by competing intra- and intermolecular interactions of the dimerization region and by the tumor suppressor p14ARF.

In vitro and in vivo studies highlight the dual regulatory effects that 7,8-dihydroxyflavone exerts on bone formation and resorption.