152 results found
    1. Neuroscience

    Mother brain is wired for social moments

    Ortal Shimon-Raz et al.
    Mother brain shows special sensitivity to social moments of mother-infant synchrony, compared to other caregiving experiences, through enhanced activation across the caregiving network, response to oxytocin administration, and temporal consistency.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    The Drosophila HNF4 nuclear receptor promotes glucose-stimulated insulin secretion and mitochondrial function in adults

    William E Barry, Carl S Thummel
    Drosophila HNF4 directs a developmental switch at the onset of adulthood that suppresses diabetes by promoting mitochondrial function and supporting glucose-stimulated insulin secretion.
    1. Biochemistry and Chemical Biology

    Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing

    Li Zhang et al.
    Inhibiting PRMT1 enzymatic activity promotes megakaryocyte terminal differentiation via RBM15-mediated RNA metabolism, which is dysregulated in hematological malignancies.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Analysis of the crystal structure of an active MCM hexamer

    Justin M Miller et al.
    Building on previous work (Froelich et al., 2014), we present the X-ray crystal structure of an active MCM hexamer, which suggests a mechanism for MCM regulation and demonstrates a key interaction between the major domains.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism

    Juraj Ahel et al.
    RNF213 is a giant E3 ligase with a dynein-like core and a unique ubiquitination mechanism that proceeds in a RING-independent manner and is linked with the Moyamoya disease.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint

    Nicolas Bigot et al.
    Two phosphorylation sites on 53BP1 are found to mediate interaction with TOPBP1-RAD9 and shown to be essential for assembling the G1 DNA damage checkpoint response apparatus.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling

    Lukasz Kedzierski et al.
    The intracellular SOCS5 protein has a unique and key role in restraining influenza A infection by regulating epidermal growth factor receptor signaling in airway epithelial cells.
    1. Cell Biology
    2. Neuroscience

    MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin

    Jina Yun et al.
    By reducing mitochondrial fusion, MUL1 compensates for the mutations in PINK1 or parkin that underlie certain cases of Parkinson's disease.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    FAK/PYK2 promotes the Wnt/β-catenin pathway and intestinal tumorigenesis by phosphorylating GSK3β

    Chenxi Gao et al.
    Dual FAK/PYK2 kinase inhibition disrupts GSK3β phosphorylation and may present a new treatment for colorectal cancer in patients carrying APC mutations.
    1. Structural Biology and Molecular Biophysics

    Structural basis for allosteric control of the SERCA-Phospholamban membrane complex by Ca2+ and phosphorylation

    Daniel K Weber et al.
    A spectroscopic analysis of the sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)-phospholamban membrane complex reveals the importance of the relative transmembrane orientation for inhibition or activation of the ATPase.

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