149 results found
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    Pyrophosphate modulates plant stress responses via SUMOylation

    M Görkem Patir-Nebioglu et al.
    In vivo inhibition of SUMO activating E1-enzymes by pyrophosphate reveals a mode of integrating metabolism and stress tolerance that is conserved across kingdoms.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Shigella entry unveils a calcium/calpain-dependent mechanism for inhibiting sumoylation

    Pierre Lapaquette et al.
    Shigella infection induces a calpain-mediated loss of SUMO conjugates that promotes bacterial entry.
    1. Evolutionary Biology

    Robust and accurate prediction of residue–residue interactions across protein interfaces using evolutionary information

    Sergey Ovchinnikov et al.
    Co-evolving residue pairs in the different components of a protein complex almost always make contact across the protein–protein interface, thus providing powerful restraints for the modeling of protein complexes.
    1. Genetics and Genomics
    2. Neuroscience

    Mutation in ATG5 reduces autophagy and leads to ataxia with developmental delay

    Myungjin Kim et al.
    A genetic mutation that impairs autophagic flux leads to neurodegeneration and can cause ataxia and developmental delay in children.
    1. Biochemistry and Chemical Biology

    SENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin-RING ubiquitin ligase function

    Kate E Coleman et al.
    Aberrant neddylation of non-cullin substrates disrupts normal cell cycle progression.
    1. Neuroscience

    Nedd4 E3 ligase and beta-arrestins regulate ubiquitination, trafficking, and stability of the mGlu7 receptor

    Sanghyeon Lee et al.
    β-arrestins recruit Nedd4 ubiquitin E3 ligase to mGlu7 receptor and facilitate ubiquitination, endocytosis, ERK signaling, and stability of mGlu7 at presynaptic terminals.
    1. Biochemistry and Chemical Biology

    Dwarf open reading frame (DWORF) is a direct activator of the sarcoplasmic reticulum calcium pump SERCA

    M'Lynn E Fisher et al.
    Activation of the sarcoplasmic reticulum calcium pump and enhancement of cellular calcium homeostasis by dwarf open reading frame reveal how this small membrane protein opposes phospholamban inhibitory function in cardiac muscle.
    1. Structural Biology and Molecular Biophysics

    A conformational switch regulates the ubiquitin ligase HUWE1

    Bodo Sander et al.
    The cancer-associated human ubiquitin ligase HUWE1 can adopt an auto-inhibited dimeric state, whose occupancy is regulated by competing intra- and intermolecular interactions of the dimerization region and by the tumor suppressor p14ARF.
    1. Medicine

    7,8-Dihydroxyflavone modulates bone formation and resorption and ameliorates ovariectomy-induced osteoporosis

    Fan Xue et al.
    In vitro and in vivo studies highlight the dual regulatory effects that 7,8-dihydroxyflavone exerts on bone formation and resorption.

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