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CFTR modulators have potent innate anti-inflammatory properties that can be measured in clinic, both ex vivo and in vitro, which can be used to predict treatment efficacy.

Severely immunodeficient B2m-NOG mice transplanted with human peripheral blood mononuclear cells from multiple sclerosis patients partially reproduce disease immunopathology and represent novel experimental models for studying human immune responses to the central nervous system in a rapid and personalized manner.

Experiments at synapses between nerve and muscle cells in genetically modified fruit flies reveal how neurons compensate for perturbations that would otherwise cause excessive synaptic transmission.

A novel pheromone/receptor neuron pair mediates attraction between Drosophila larvae, and evolved differences in pheromone signaling underlie changes in social behavior between drosophilid species.

Genome-wide RNA-seq analysis of single cells of the developing mouse endolymphatic sac reveals its molecular-cellular architecture and a model for salt and fluid absorption required for acquisition of normal inner ear structure and function.

The ion channel ppk301 is required for the evaluation of water purity during egg-laying, which promotes offspring survival in the arboviral vector mosquito Aedes aegypti.

Manipulating the activity of ‘stretch-sensitive’ ion channels in neurons innervating the digestive system of fruit flies has dramatic effects on food intake, suggesting that these ion channels could be targets for drugs to help tackle obesity.

An interaction between the ion channel ASIC1a and the protein RIP1 is responsible for neuronal death caused by tissue acidosis.

Mapping the ion permeation pathway within the internal pore of ATP-activated P2X receptor channels.