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    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Crk proteins transduce FGF signaling to promote lens fiber cell elongation

    Tamica N Collins et al.
    Crk proteins are critical mediators of FGF signaling to control cell shape changes.
    1. Cancer Biology

    KLK3/PSA and cathepsin D activate VEGF-C and VEGF-D

    Sawan Kumar Jha et al.
    Both VEGF-C and VEGF-D can be activated by KLK3/PSA and Cathepsin D, producing two novel VEGF-C forms and the known VEGFR-2-specific form of VEGF-D.
    1. Neuroscience

    VEGF signaling regulates the fate of obstructed capillaries in mouse cortex

    Patrick Reeson et al.
    Mapping the fate of clogged brain capillaries reveals that VEGF signaling plays a critical role in dictating whether capillaries regain blood flow and persist or are pruned from the vascular tree.
    1. Developmental Biology

    The flow responsive transcription factor Klf2 is required for myocardial wall integrity by modulating Fgf signaling

    Seyed Javad Rasouli et al.
    Endocardial Klf2 regulates cardiomyocyte adhesion and myocardial wall integrity by modulating FGF signaling in zebrafish.
    1. Developmental Biology

    BMP and FGF signaling interact to pattern mesoderm by controlling basic helix-loop-helix transcription factor activity

    Richard H Row et al.
    Interplay between FGF-induced bHLH transcription factors and BMP-induced bHLH inhibitory id genes govern mesodermal cell fate choice along the mediolateral axis in both zebrafish and mouse.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition

    Anassuya Ramachandran et al.
    SMAD1/5 signaling is essential for the full transforming growth factor β (TGF-β)-induced transcriptional program and physiological responses and is induced via a novel receptor activation mechanism, involving two distinct type I receptors.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling

    Yosuke Yoneyama et al.
    IRS-1, a canonical signaling mediator of IGF-I receptor, serves as an endocytic regulator of IGF-I receptor to facilitate the sustained IGF signaling.
    1. Developmental Biology

    FGF mediated MAPK and PI3K/Akt Signals make distinct contributions to pluripotency and the establishment of Neural Crest

    Lauren Geary, Carole LaBonne
    A role for FGF-mediated Map Kinase signaling in the retention of pluripotency underlying genesis of Neural Crest is revealed, along with a striking switch in the signaling cascades activated by FGF signaling as cells commence lineage restriction.
    1. Cell Biology
    2. Computational and Systems Biology

    Dynamic NF-κB and E2F interactions control the priority and timing of inflammatory signalling and cell proliferation

    John M Ankers et al.
    Cell imaging and mathematical modelling show reciprocal cross-regulation between inflammatory signalling and cell cycle timing, which is mediated through functional interactions between NF-B and E2F proteins.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    EGFR signaling promotes self-renewal through the establishment of cell polarity in Drosophila follicle stem cells

    Angela Castanieto et al.
    The specification of cell polarity is essential for self-renewal and the segregation of stem-cell and daughter-cell fates in an epithelial stem cell lineage.