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Marked synergy by vertical inhibition of EGFR signaling in NSCLC spheroids shows SOS1 is a therapeutic target in EGFR-mutated cancer
Patricia L Theard et al.
Combined EGFR and SOS1 inhibition synergize to inhibit NSCLC spheroid growth.
Structural Biology and Molecular Biophysics
Her2 activation mechanism reflects evolutionary preservation of asymmetric ectodomain dimers in the human EGFR family
Anton Arkhipov et al.
The structural basis for Her2's role as a dedicated heterodimerization partner for other EGFR family receptors is elucidated with long-timescale atomistic simulations.
The CHORD protein CHP-1 regulates EGF receptor trafficking and signaling in
and in human cells
Andrea Haag et al.
The co-chaperone CHORDC1 is specifically required for epidermal growth factor receptor trafficking and signaling in
and in human cells.
N-cadherin-regulated FGFR ubiquitination and degradation control mammalian neocortical projection neuron migration
Elif Kon et al.
FGFRs regulate multipolar cortical neuron orientation and the morphological change into bipolar cells in vivo under the control of N-Cadherin and the extracellular matrix protein Reelin.
Microbiology and Infectious Disease
Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling
Lukasz Kedzierski et al.
The intracellular SOCS5 protein has a unique and key role in restraining influenza A infection by regulating epidermal growth factor receptor signaling in airway epithelial cells.
Biochemistry and Chemical Biology
O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals
Shogo Sawaguchi et al.
The transfer of O-GlcNAc by EOGT to specific EGF repeats of NOTCH1 promotes DLL4 binding, Notch signaling, and retinal vascular development.
Regulation of EGFR signal transduction by analogue-to-digital conversion in endosomes
Roberto Villaseñor et al.
Cells package active receptors in endosomes at fairly constant amounts and can determine different cell-fate decisions by regulating the number and lifetime of receptor packages.
Diversification of heart progenitor cells by EGF signaling and differential modulation of ETS protein activity
Benjamin Schwarz et al.
A novel regulatory model for the diversification of cardiac cell subpopulations in
is established by linking epidermal growth factor signaling with differential activities of key transcription factors.
Evidence that synthetic lethality underlies the mutual exclusivity of oncogenic KRAS and EGFR mutations in lung adenocarcinoma
Arun M Unni et al.
Co-mutation of two powerful oncogenes in certain cell types may have a lethal effect that explains the mutual exclusivity of the mutations.
is a post-mitotic regulator of planarian epidermal differentiation
Kimberly C Tu et al.
The dynamic homeostasis of the planarian epidermis serves as an experimental paradigm to study stem cell dynamics and post-mitotic specification of diverse functional cell fates.
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