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    1. Neuroscience

    Decoding gripping force based on local field potentials recorded from subthalamic nucleus in humans

    Huiling Tan et al.
    Patterns of coordinated activity in the basal ganglia predict how much force we will use to grip objects, suggesting that individuals with paralysis may ultimately be able to use these signals to control graded responses in robotic devices.
    1. Stem Cells and Regenerative Medicine

    ANGPTL4 mediates shuttling of lipid fuel to brown adipose tissue during sustained cold exposure

    Wieneke Dijk et al.
    During sustained cold exposure, lipid fuel is specifically directed towards brown adipose tissue, but not white adipose tissue, via cold-induced regulation of Angiopoietin-like 4 (ANGPTL4).
    1. Neuroscience

    Thalamic reticular nucleus induces fast and local modulation of arousal state

    Laura D Lewis et al.
    A neural circuit that can selectively induce sleep-like patterns in small regions of the brain demonstrates how sleep and arousal states may be controlled in local brain regions.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Two-way communication between SecY and SecA suggests a Brownian ratchet mechanism for protein translocation

    William John Allen et al.
    Evidence is presented that supports a completely new, diffusion-driven mechanism for transporting proteins across membranes in bacteria.
    1. Developmental Biology

    Loss of Ptpn11 (Shp2) drives satellite cells into quiescence

    Joscha Griger et al.
    The stem cells of the postnatal muscle allow postnatal muscle growth and repair and withdraw from the cell cycle when the tyrosine phosphatase Ptpn11 (Shp2) is inhibited or mutated in mice.
    1. Genetics and Genomics

    Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994

    Aline Jelenkovic et al.
    Genetic variance of adult human height shows a generally increasing trend across the birth-year cohorts but heritability estimates do not present any clear pattern of secular changes over a century.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Sir2 phosphorylation through cAMP-PKA and CK2 signaling inhibits the lifespan extension activity of Sir2 in yeast

    Woo Kyu Kang et al.
    The deacetylase Sir2 fine-tunes transcription of PMA1 and other aging related genes in a cAMP-PKA and CK2 signaling dependent manner.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    TANGO1 builds a machine for collagen export by recruiting and spatially organizing COPII, tethers and membranes

    Ishier Raote et al.
    TANGO1 creates a sub-compartment at the endoplasmic reticulum, to segregate and export fully assembled bulky cargoes.
    1. Cell Biology
    2. Neuroscience

    Clarinet (CLA-1), a novel active zone protein required for synaptic vesicle clustering and release

    Zhao Xuan et al.
    Clarinet, a novel C. elegans active zone protein with homology to vertebrate Piccolo and Rim, uses its different isoforms for diverse functions, including synaptic vesicle clustering, vesicle release and synaptogenesis.
    1. Cell Biology
    2. Neuroscience

    Activity and Ca2+ regulate the mobility of TRPV1 channels in the plasma membrane of sensory neurons

    Eric N Senning, Sharona E Gordon
    Channel activity is a novel regulatory mechanism for channel mobility in the plasma membrane.