Voice your concerns about research culture and research communication: Have your say in our 7th annual survey.
147 results found
  1. Science Writing Competition: Hip, hip, hooray!

    Emma Pewsey
    The use of X-rays to investigate why bones break could lead to treatments that reduce the number of elderly people who suffer broken hips.
    1. Chromosomes and Gene Expression

    A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics

    Nicole A Rapicavoli et al.
    A long non-coding RNA regulates the expression of genes that encode proteins involved in the inflammatory response.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation

    Ji-Eun Lee et al.
    MLL4 (KMT2D) is a major mammalian H3K4 mono- and di-methyltransferase that is essential for enhancer activation, cell-type-specific gene expression, and cell differentiation.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Multiple knockout mouse models reveal lincRNAs are required for life and brain development

    Martin Sauvageau et al.
    Long intergenic noncoding RNA molecules (lincRNAs) are shown to have critical roles in mammalian development and physiology in vivo.
    1. Chromosomes and Gene Expression

    Acetylation of histone H3 at lysine 64 regulates nucleosome dynamics and facilitates transcription

    Vincenzo Di Cerbo et al.
    The acetylation of histones at specific sites close to DNA can regulate transcription.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network

    Jerome C Nwachukwu et al.
    Anti-inflammatory effects of resveratrol are mediated by the estrogen receptor to coordinate a complex array of transcriptional coregulators, suggesting that estrogenic effects must be considered in the complex polypharmacology of resveratrol.
    1. Chromosomes and Gene Expression

    p50-associated COX-2 extragenic RNA (PACER) activates COX-2 gene expression by occluding repressive NF-κB complexes

    Michal Krawczyk, Beverly M Emerson
    A long non-coding RNA removes the transcriptional repressor p50 to regulate recruitment of co-activator p300 and RNA Polymerase II complexes to activate the COX-2 gene in human mammary epithelial cells and macrophages.
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms

    Mary Ann Allen et al.
    The first global analysis of the effects of the transcription factor p53 on RNA synthesis illuminates several novels aspects of the molecular mechanism of action of this potent tumor suppressor.
    1. Stem Cells and Regenerative Medicine
    2. Chromosomes and Gene Expression

    Mof-associated complexes have overlapping and unique roles in regulating pluripotency in embryonic stem cells and during differentiation

    Sarina Ravens et al.
    Two complexes that contain the histone acetyl transferase MOF have distinct regulatory roles in the growth and development of pluripotent embryonic stem cells
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    MOF-associated complexes ensure stem cell identity and Xist repression

    Tomasz Chelmicki et al.
    Two complexes that contain the histone acetyl transferase MOF engage in a two-pronged approach to ensure the repression of X inactivation in mouse embryonic stem cells.

Refine your results by:

Type
Research categories