406 results found
    1. Cell Biology
    2. Plant Biology

    A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress

    Madlen Stephani et al.
    C53 bridges selective autophagy with ribosome-associated quality control at the endoplasmic reticulum.
    1. Neuroscience

    MCTP is an ER-resident calcium sensor that stabilizes synaptic transmission and homeostatic plasticity

    Özgür Genç et al.
    MCTP is a novel presynaptic calcium sensor, resident within the endoplasmic reticulum, that is required for normal baseline neurotransmission, short-term synaptic plasticity and presynaptic homeostatic plasticity.
    1. Cell Biology

    The unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis

    Philipp Kimmig et al.
    A unique form of regulation has been observed in the unfolded protein response of S. pombe, along with a novel mechanism of post-transcriptional mRNA processing.
    1. Cell Biology

    Selective clearance of the inner nuclear membrane protein emerin by vesicular transport during ER stress

    Abigail Buchwalter et al.
    Emerin, a protein that plays key roles in nuclear organization, can be dynamically degraded in response to environmental stimuli such as ER stress.
    1. Cell Biology

    Ratiometric sensing of BiP-client versus BiP levels by the unfolded protein response determines its signaling amplitude

    Anush Bakunts et al.
    Restoration of endoplasmic reticulum (ER) homeostatis occurs when levels of the key ER resident chaperone BiP exceed those of accumulating ER clients.
    1. Cell Biology

    Cell Biology: New twists in the unfolded protein response

    Benedict C S Cross, David Ron
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    1. Cell Biology

    Identification and dynamics of the human ZDHHC16-ZDHHC6 palmitoylation cascade

    Laurence Abrami et al.
    Cycles of palmitoylation-depalmitoylation by an upstream palmitoyltransferase allow precise tuning of DHHC6 activity, which in turn regulates the abundance and function of key ER proteins involved in protein folding, degradation, ER architecture and calcium homeostasis.
    1. Stem Cells and Regenerative Medicine

    Insulin: Folding mutations suppress early beta-cell proliferation

    Honey Modi, James D Johnson
    Exploring how proliferation and maturation of beta-cells can be impaired after birth will shed light on the origins of various forms of diabetes.
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    1. Cancer Biology
    2. Chromosomes and Gene Expression

    A small protein encoded by a putative lncRNA regulates apoptosis and tumorigenicity in human colorectal cancer cells

    Xiao Ling Li et al.
    Discovery and initial characterization of a conserved small protein translated from a transcript annotated as a human long non-coding RNA.
    1. Biochemistry and Chemical Biology

    Bacterial OTU deubiquitinases regulate substrate ubiquitination upon Legionella infection

    Donghyuk Shin et al.
    A novel class of bacterial OTU deubiquitinases provides insights on the distinct roles of bacterial deubiquitinases in host–pathogen interactions.

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