Edward R Kastenhuber, Marisa Mercadante ... Lewis Cantley
Factor Xa and thrombin cleavage activate SARS-CoV-2 spike, widening the scope of host proteases involved in coronavirus entry and demonstrating the potential for dual anticoagulant/antiviral drugs.
Constitutive activation of an innate immunity response in mouse brain causes degeneration of dopaminergic neurons, suggesting novel targets for potentially neuroprotective strategies.
Single-cell RNA sequencing reveals HLJ1 as a novel immunomodulator for multicellular pathway of macrophages and NK cells, contributing to organ injury and sepsis death through amplified IL-12/IFN-γ axis.
Jenna R Christensen, Glen M Hocky ... David R Kovar
Both cooperative and competitive associations of actin binding proteins with actin filaments help drive the self-organization of functionally diverse F-actin networks in fission yeast.
Zaki A Sherif, Christian R Gomez ... RECOVER Mechanistic Pathway Task Force
PASC (post-acute sequelae of SARS-CoV-2 infection) is an enduring and debilitating illness caused by a persistent virus that promotes inflammation, coagulation, and autoimmunity complications in millions of patients initially diagnosed with COVID-19, but with no known standardized treatment regimen.
Rebecca Devlin, Catarina A Marques ... Richard McCulloch
Mapping DNA replication timing, allied to genetic analysis of a RecQ repair helicase, reveals that antigenic variation in the African trypanosome may be initiated by locus-specific, replication-derived sequence instability.
