830 results found
    1. Cell Biology

    Selective clearance of the inner nuclear membrane protein emerin by vesicular transport during ER stress

    Abigail Buchwalter et al.
    Emerin, a protein that plays key roles in nuclear organization, can be dynamically degraded in response to environmental stimuli such as ER stress.
    1. Cell Biology

    A sphingolipid-dependent diffusion barrier confines ER stress to the yeast mother cell

    Lori Clay et al.
    Sphingolipids govern the compartmentalization of yeast cells through the assembly of lateral diffusion barriers in ER membranes.
    1. Cell Biology
    2. Genetics and Genomics

    Inhibition of mTORC1 by ER stress impairs neonatal β-cell expansion and predisposes to diabetes in the Akita mouse

    Yael Riahi et al.
    mTORC1 inhibition by perinatal ER stress induces beta-cell growth arrest with subsequent development of diabetes.
    1. Cell Biology

    The proteasome biogenesis regulator Rpn4 cooperates with the unfolded protein response to promote ER stress resistance

    Rolf M Schmidt et al.
    Endoplasmic reticulum stress in yeast activates not only the UPR but also Rpn4, promoting the clearance of misfolded proteins from the cytosol as part of a modular cross-compartment stress response.
    1. Cell Biology

    Ceapins inhibit ATF6α signaling by selectively preventing transport of ATF6α to the Golgi apparatus during ER stress

    Ciara M Gallagher, Peter Walter
    Ceapins specifically inhibit ATF6α signaling by preventing its transport to the Golgi during endoplasmic reticulum stress.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Noncanonical binding of BiP ATPase domain to Ire1 and Perk is dissociated by unfolded protein CH1 to initiate ER stress signaling

    Marta Carrara et al.
    The chaperone protein BiP forms complexes with Ire1 and Perk that dissociate when unfolded proteins bind to BiP to activate the unfolded protein response in the ER.
    1. Cell Biology

    Nuclear receptor LRH-1/NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution

    Jennifer L Mamrosh et al.
    LRH-1/NR5A2 responds to ER stress by inducing a novel pathway that is required for stress resolution in mice and can be targeted by LRH-1 agonists.
    1. Cell Biology
    2. Plant Biology

    A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress

    Madlen Stephani et al.
    C53 bridges selective autophagy with ribosome-associated quality control at the endoplasmic reticulum.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Pre-existing bilayer stresses modulate triglyceride accumulation in the ER versus lipid droplets

    Valeria Zoni et al.
    In parallel to protein-driven processes, characteristic physicochemical properties of the endoplasmic reticulum membrane modulate intracellular fat accumulation and lipid droplet formation.
    1. Cell Biology

    The ER Stress Surveillance (ERSU) pathway regulates daughter cell ER protein aggregate inheritance

    Francisco J Piña, Maho Niwa
    Endoplasmic reticulum (ER) inheritance regulation during ER stress controls the transmission of misfolded ER proteins from mother to daughter cell in budding yeast.

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