744 results found
    1. Neuroscience

    Stress diminishes outcome but enhances response representations during instrumental learning

    Jacqueline Katharina Meier, Bernhard P Staresina, Lars Schwabe
    Decoding of neural outcome and response representations allows dissecting goal-directed and habitual contributions to behaviour and reveals how acute stress biases the instrumental control of behaviour.
    1. Computational and Systems Biology

    Recurrent neural networks enable design of multifunctional synthetic human gut microbiome dynamics

    Mayank Baranwal, Ryan L Clark ... Ophelia S Venturelli
    Recurrent neural network models enable prediction and design of health-relevant metabolite dynamics in synthetic human gut communities.
    1. Cell Biology

    Growth-dependent signals drive an increase in early G1 cyclin concentration to link cell cycle entry with cell growth

    Robert A Sommer, Jerry T DeWitt ... Douglas R Kellogg
    A G1 cyclin shows key properties expected of a protein that could link cell cycle progression to cell growth.
    1. Microbiology and Infectious Disease

    Reverting the mode of action of the mitochondrial FOF1-ATPase by Legionella pneumophila preserves its replication niche

    Pedro Escoll, Lucien Platon ... Carmen Buchrieser
    During infection, L. pneumophila reverses the ATP-synthase activity of the mitochondrial FOF1-ATPase to ATP-hydrolase activity in a type 4 secretion-dependent manner to prevent early cell death, thereby preserving its replication niche.
    1. Computational and Systems Biology
    2. Neuroscience

    High-resolution volumetric imaging constrains compartmental models to explore synaptic integration and temporal processing by cochlear nucleus globular bushy cells

    George A Spirou, Matthew Kersting ... Paul B Manis
    Volume electron-microscopic reconstructions of auditory brainstem neurons and their afferent synapses were used to develop a pipeline creating biophysically defined computational models with heterogenous inputs, revealing roles for subthreshold synapses to enhance temporal processing unique features of their dendrites.
    1. Cell Biology
    2. Computational and Systems Biology

    Cell size sensing in animal cells coordinates anabolic growth rates and cell cycle progression to maintain cell size uniformity

    Miriam Bracha Ginzberg, Nancy Chang ... Marc W Kirschner
    Cells employ two strategies, adjusting both their cell cycle lengths and their growth rates in a size-dependent manner, to correct aberrations in cell size.
    1. Neuroscience

    Recording γ-secretase activity in living mouse brains

    Steven S Hou, Yuya Ikegawa ... Masato Maesako
    A new imaging tool to record γ-secretase activity in vivo.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Nicotinic acetylcholine receptor signaling maintains epithelial barrier integrity

    Nadja S Katheder, Kristen C Browder ... Heinrich Jasper
    Signaling through nicotinic acetylcholine receptors in enterocytes impacts barrier integrity in the Drosophila intestine by regulating formation of the peritrophic matrix.
    1. Developmental Biology

    mTORC1-induced retinal progenitor cell overproliferation leads to accelerated mitotic aging and degeneration of descendent Müller glia

    Soyeon Lim, You-Joung Kim ... Jin Woo Kim
    Comprehensive mouse genetic analyses show, by having mTORC1 constitutively active, a RPC divides and exhausts mitotic capacity faster than neighboring RPCs, and thus produces retinal cells that degenerate with aging-related changes in the mature mouse retina.
    1. Cell Biology

    A versatile oblique plane microscope for large-scale and high-resolution imaging of subcellular dynamics

    Etai Sapoznik, Bo-Jui Chang ... Reto P Fiolka
    A novel single-objective light-sheet microscope with unparalleled spatiotemporal resolution enables imaging and optical manipulation of diverse biological specimens and processes.

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