5,108 results found
    1. Evolutionary Biology

    Long read sequencing reveals poxvirus evolution through rapid homogenization of gene arrays

    Thomas A Sasani et al.
    An adaptive process of genetic homogenization in poxviruses facilitates the propagation of single nucleotide variation within gene copies and might favor the persistence of large gene copy arrays.
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    Pervasive transcription read-through promotes aberrant expression of oncogenes and RNA chimeras in renal carcinoma

    Ana R Grosso et al.
    Transcription beyond annotated gene boundaries expands the diversity of the cancer transcriptome with overexpressed oncogenes and RNA chimeras.
    1. Microbiology and Infectious Disease

    RNA polymerase mutations cause cephalosporin resistance in clinical Neisseria gonorrhoeae isolates

    Samantha G Palace et al.
    Ceftriaxone resistance has arisen multiple times in clinical gonococcal populations via previously undescribed RNA polymerase mutations, underscoring the importance of continued surveillance for novel resistance determinants.
    1. Neuroscience

    A thesaurus for a neural population code

    Elad Ganmor et al.
    The activity patterns of populations of neurons in the retina are organized as semantic clusters (analogous to synonyms), in which component patterns bear little physical resemblance to one another but convey the same meaning.
    1. Neuroscience

    The roles of online and offline replay in planning

    Eran Eldar et al.
    Replay of recently experienced trajectories during a decision task is coupled with more effective adaptation to change, whereas replay during rest is associated with limited decision making flexibility.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Cycles of autoubiquitination and deubiquitination regulate the ERAD ubiquitin ligase Hrd1

    Brian G Peterson et al.
    The Hrd1-centric endoplasmic reticulum associated degradation system is regulated by interplay between the system's components.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Sterol homeostasis requires regulated degradation of squalene monooxygenase by the ubiquitin ligase Doa10/Teb4

    Ombretta Foresti et al.
    Parallel branches of the ERAD pathway regulate sterol synthesis at multiple steps via feedback inhibition.
    1. Genetics and Genomics

    Distinct mitochondrial defects trigger the integrated stress response depending on the metabolic state of the cell

    Eran Mick et al.
    Mitochondrial electron transport chain dysfunction triggers the integrated stress response due to an asparagine deficiency downstream of impaired NADH oxidation in proliferating myoblasts, but not in differentiated myotubes.
    1. Evolutionary Biology

    An adjunctive therapy administered with an antibiotic prevents enrichment of antibiotic-resistant clones of a colonizing opportunistic pathogen

    Valerie J Morley et al.
    Cholestyramine, an FDA-approved bile acid sequestrant, can be repurposed to inactivate the antibiotic daptomycin in the gut, which prevents the emergence of transmissible antibiotic resistance in gastrointestinal Enterococcus faecium populations.
    1. Neuroscience

    Activity patterns of serotonin neurons underlying cognitive flexibility

    Sara Matias et al.
    Recordings from serotonin-producing neurons in the brain reveal that these neurons are highly activated by sudden changes in previously familiar environments, potentially explaining why serotonin is important for learning to adapt to such changes.

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