Pleiotropic loci that play a role in multiple neuropsychiatric diseases exist, but many of them might contribute to each disease via a distinct mechanism.

A peptidergic network translates internal nutrient abundance cues into the coordinated regulation of sugar and water ingestion.

Studies of organoid morphogenesis, combined with proteomics and molecular profiling, identify the THBS1-YAP axis as a signalling mechanism that mediates paracrine communication between tumour cells and their wildtype epithelial neighbours.

Studies in mice and neurons reveal how modulation of the axonal transport of synaptic vesicles via huntingtin phosphorylation influences the number of vesicles accumulating at the synapse, subsequent glutamate release, and behavior in mice.

Biochemical and genetic approaches uncover a chromatin remodeler for PRDM9 binding and the parallel local epigenetic modification of cytosines in mouse spermatocytes.

Plasma membrane clusters of the Parkinson's disease protein α-synuclein colocalize with negatively charged phospholipids involved in endocytosis and exocytosis.

The expression of human L1 retrotransposons is highly locus-specific and variable between different cell types.

During aging, the pancreatic endocrine islets undergo chronic inflammation, which is associated with a reduced capacity for self-renewal of the insulin-producing beta-cells in zebrafish.

LncRNAs are important to stabilize postmitotic cell fate of spinal motor neurons.

CryoEM reveals the structure of a two-component archaeal S-layer, which sheds new light on archaeal cell biology.